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Clinical Outcomes of Endothelial Keratoplasty With a Recipient's Entire Descemet Stripping for Iridocorneal Endothelial Syndrome.

Am J Ophthalmol

February 2025

From the State Key Laboratory of Ophthalmology (X.D., C.O., J.W., C.X., L.F., M.M., J.P., T.H.), Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. Electronic address:

Article Synopsis
  • The study aimed to determine if completely removing the recipient's Descemet membrane reduces endothelial cell loss (ECL) after Descemet membrane endothelial keratoplasty (DMEK) for patients with iridocorneal endothelial (ICE) syndrome.
  • It was a randomized controlled trial that compared two groups of patients: one receiving full Descemet stripping and the other undergoing a standard technique.
  • Results showed that those in the entire stripping group experienced significantly lower ECL rates after 9 months, suggesting this technique could help manage ICE syndrome better, although overall visual acuity and complication rates were similar between the two groups.
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