AI Article Synopsis
- A precise diagnosis is crucial for effectively managing allergic diseases and asthma, but traditional methods with allergen extracts often miss the specific molecules causing reactions.
- Component-resolved diagnosis (CRD) addresses these limitations and is now a valuable tool in allergy clinics, helping differentiate between true sensitivities and cross-reactivity, predict severe allergic reactions, and tailor allergen immunotherapy.
- CRD represents a shift towards precision immunology, enhancing the management of allergic conditions by offering a more detailed understanding of patient sensitization profiles.
Article Abstract
Introduction: A precise diagnosis is key for the optimal management of allergic diseases and asthma. or diagnostic methods that use allergen extracts often fail to identify the molecules eliciting the allergic reactions.
Areas Covered: Component-resolved diagnosis (CRD) has solved most of the limitations of extract-based diagnostic procedures and is currently valuable tool for the precision diagnosis in the allergy clinic, for venom and food allergy, asthma, allergic rhinitis, and atopic dermatitis. Its implementation in daily practice facilitates: a) the distinction between genuine multiple sensitizations and cross-reactive sensitization in polysensitized patients; b) the prediction of a severe, systemic reaction in food or insect venom allergy; c) the optimal selection of allergen immunotherapy based on the patient sensitization profile. This paper describes its main advantages and disadvantages, cost-effectiveness and future perspectives.
Expert Opinion: The diagnostic strategy based on CRD is part of the new concept of precision immunology, which aims to improve the management of allergic diseases.
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| http://dx.doi.org/10.1080/1744666X.2022.2034501 | DOI Listing |
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