Automated vehicle steering control systems have great potential to improve road safety. The development of such systems calls for mathematical driver models able to represent human drivers' steering behavior in response to automated steering intervention. This article concerns the experimental evaluation of a game-theoretic driver steering control model. The driver model centers on a steering control strategy developed based on the Nash equilibrium of a theoretic noncooperative game between the driver and automated steering controller. The key parameters of the game-theoretic driver model are identified by fitting the model to real driver steering behavior measured from six driver subjects in an experiment using a driving simulator. The game-theoretic driver model is evaluated by compared to a "conventional" optimal-control-theoretic driver model, and analyzing their model fitting errors. Results from the analysis demonstrate that the game-theoretic driver model is statistically significantly better than the conventional driver model for representing three out of the six subjects' steering behavior. For the other three subjects, both the two models perform statistically equivalently well.
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http://dx.doi.org/10.1109/TCYB.2022.3140362 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS 66045.
Climate change is increasing the frequency of large-scale, extreme environmental events and flattening environmental gradients. Whether such changes will cause spatially synchronous, large-scale population declines depends on mechanisms that limit metapopulation synchrony, thereby promoting rescue effects and stability. Using long-term data and empirical dynamic models, we quantified spatial heterogeneity in density dependence, spatial heterogeneity in environmental responses, and environmental gradients to assess their role in inhibiting synchrony across 36 marine fish and invertebrate species.
View Article and Find Full Text PDFJ Healthc Manag
January 2025
Division of Health Care Delivery Research, Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Jacksonville, Florida.
Goal: While studies have examined quality and health outcomes related to the Centers for Medicare & Medicaid Services' (CMS's) Hospital Value-Based Purchasing (HVBP) Program, a significant gap exists in the literature regarding the relationship between pay-for-performance initiatives and hospital financial performance in the program's Efficiency and Cost Reduction domain. This study examined the association between hospitals' cost inefficiency and participation in the HVBP Program by estimating the probability and magnitude of improvement or achievement in the program's Efficiency and Cost Reduction domain.
Methods: The 2014-2019 Efficiency and Cost Reduction domain data were obtained from CMS and merged with the American Hospital Association's Annual Survey Database.
Environ Sci Technol
January 2025
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China.
Atmospheric elemental mercury (Hg) assimilation by foliage contributes prevalently to the global atmospheric Hg sink in forests. Today, little is known about the mechanisms of foliar Hg accumulation and how climate factors and tree physiology interact to impact it. Here, we examined meteorological factors, foliar physiological traits, and Hg accumulation rates from leaf emergence to senescence in a tropical rainforest, tropical savanna, and subtropical evergreen broadleaf forest.
View Article and Find Full Text PDFCell Rep
January 2025
Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:
Hepatic stellate cells (HSCs) are key drivers of local fibrosis. Adiponectin, conventionally thought of as an adipokine, is also expressed in quiescent HSCs. However, the impact of its local expression on the progression of liver fibrosis remains unclear.
View Article and Find Full Text PDFCells
December 2024
Department of Herbal Pharmacology, College of Korean Medicine, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
The NLRP3 inflammasome, plays a critical role in the pathogenesis of rheumatoid arthritis (RA) by activating inflammatory cytokines such as IL1β and IL18. Targeting NLRP3 has emerged as a promising therapeutic strategy for RA. In this study, a multidisciplinary approach combining machine learning, quantitative structure-activity relationship (QSAR) modeling, structure-activity landscape index (SALI), docking, molecular dynamics (MD), and molecular mechanics Poisson-Boltzmann surface area MM/PBSA assays was employed to identify novel NLRP3 inhibitors.
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