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| http://dx.doi.org/10.1021/acs.biomac.2c00045 | DOI Listing |
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Neglecting the impact of normalization in semi-synthetic RNA-seq data simulations generates artificial false positives.
Genome Biol
October 2024
RAND Corporation, 90401, Santa Monica, CA, USA.
A recent study reported exaggerated false positives by popular differential expression methods when analyzing large population samples. We reproduce the differential expression analysis simulation results and identify a caveat in the data generation process. Data not truly generated under the null hypothesis led to incorrect comparisons of benchmark methods.
View Article and Find Full Text PDFEngineered Skin Substitutes in Dermatologic Surgery: A Systematic Review.
Dermatol Surg
December 2024
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadephia, Pennsylvania.
Background: Artificial skin substitutes are a flexible alternative to autografting in Mohs micrographic surgery (MMS), but the characteristics and clinical outcomes of skin substitutes are not well defined.
Objective: Summarize clinical data of skin substitutes in MMS for cutaneous malignancy.
Methods: A MEDLINE/Embase/Web of Science search was conducted.
[Influence of the rat diet enrichment with oat β-gucans on the assimilation of B group vitamins, mineral elements and lipid metabolism].
Vopr Pitan
April 2024
Siberian State Medical University, Ministry of Health of the Russian Federation, 634050, Tomsk, Russian Federation.
Article Synopsis
- The study aimed to investigate how oat bran rich in β-glucans affects the absorption of vitamins and minerals, particularly in rats with deficiencies in vitamins D, B group, and trace elements like iron, copper, and zinc.
- After a period of 23 days inducing micronutrient deficiencies, rats were given a semi-synthetic diet supplemented with missing micronutrients for 7 days, with some groups also receiving β-glucans.
- Results showed that replenishing vitamins B1, B2, and B6 eliminated deficiencies, while β-glucans enhanced iron absorption, evidenced by increased plasma iron levels and decreased urinary iron excretion.
Magnesium-ibogaine therapy in veterans with traumatic brain injuries.
Nat Med
February 2024
Brain Stimulation Lab, Department of Psychiatry & Behavioral Sciences, Stanford School of Medicine, Stanford, CA, USA.
Article Synopsis
- Traumatic brain injury (TBI) can lead to long-term issues for veterans, such as PTSD, depression, and anxiety, particularly among Special Operations Forces veterans (SOVs).
- A study called MISTIC explored the use of magnesium combined with the plant-derived compound ibogaine, focusing on its effects on 30 male SOVs with mild TBI.
- The study reported significant improvements in functioning and reductions in PTSD, depression, and anxiety one month after treatment, with no major adverse effects noted, but further clinical trials are necessary to confirm these results.
Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer.
Evol Bioinform Online
December 2023
Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
The overexpression of the Epidermal Growth Factor Receptor (EGFR) marks it as a pivotal target in cancer treatment, with the aim of reducing its proliferation and inducing apoptosis. This study aimed at the CADD of a new apoptotic EGFR inhibitor. The natural alkaloid, theobromine, was used as a starting point to obtain a new semisynthetic (di-ortho-chloro acetamide) derivative ().
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