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The Frequency of c.557A>G in the Dominican Population and Its Association with African Ancestry.
Pharmaceutics
December 2024
Personalized Medicine and Mental Health Unit, University Institute for Bio-Sanitary Research of Extremadura, 06080 Badajoz, Spain.
Genetic polymorphism of the dihydropyrimidine dehydrogenase gene () is responsible for the variability found in the metabolism of fluoropyrimidines such as 5-fluorouracil (5-FU), capecitabine, or tegafur. The genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10-40% of patients treated with fluoropyrimidines develop severe toxicity.
View Article and Find Full Text PDFThe hygienic insecticide dimefluthrin induced neurodevelopmental deficits and behavioral disorders in zebrafish (Danio rerio) larvae.
Environ Res
January 2025
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address:
Hygienic insecticides are applied directly to the living environment and are closely related to human life. Dimefluthrin (DIM) is one of the most widely used hygienic insecticides globally. However, with increasing mosquito resistance, both the concentration and duration of DIM usage have risen, prompting public concerns regarding its neurotoxic risks, especially for immunocompromised children.
View Article and Find Full Text PDF[Effect of low-intensity laser-therapy in the correction of encephalopathy in obstructive jaundice].
Vopr Kurortol Fizioter Lech Fiz Kult
December 2024
Polyclinic No. 3 of the Medical Sanitary Unit of the Ministry of Internal Affairs of the Russian Federation, Moscow, Russia.
Unlabelled: Hepatic encephalopathy is an early and severe complication of obstructive jaundice and is characterized by occurrence of non-focal and focal neurological manifestations. Different methods of therapy are applied for disorder correction. Low-intensity laser blood irradiation has a pronounced antioxidant and vasoactive effect.
View Article and Find Full Text PDFAssessment of knowledge and behavioral risk factors of reproductive tract infections among married women of 15-49 years in rural areas of Haldwani block, Uttarakhand.
J Family Med Prim Care
October 2024
Department of Urology, Himalayan Institute of Medical Sciences, Swami Ram Himalayan University, Dehradun, Uttarakhand, India.
Background: One of the most serious public health issues in India is reproductive tract infections (RTIs), which have a profound effect on the lives of men and women, as well as their families and communities.
Objectives: To describe the sociodemographic traits, assess women's RTI knowledge, and determine which behavioral risk factors are involved in female RTI.
Methods: Using a 30-cluster sampling approach, a cross-sectional study design was employed to examine RTIs in 30 villages located in the Haldwani block of the district Nainital.
Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB.
EMBO Mol Med
January 2025
The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Article Synopsis
- Melanin-like nanoparticles (MNPs) are emerging as effective antioxidant therapy agents due to their biocompatibility and ability to scavenge reactive oxygen species (ROS), but research on their effects in chronic diseases is still limited.
- In this study, researchers created an ultra-small formulation called MMPP, which was shown to accumulate in renal tubules and significantly reduce oxidative stress and cyst growth in a model of autosomal dominant polycystic kidney disease (ADPKD).
- The mechanism behind MMPP's therapeutic potential involves its binding to the CREB protein, which inhibits gene expression related to cyst growth, thus providing a dual approach to treating oxidative stress and disease progression in ADPKD.
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