Objective: Current findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis.
Methods: Eligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as "MMP-9", "matrix metallopeptidase-9" and "myocardial infarction", "acute myocardial infarction", "AMI", and "polymorphism". Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0.
Results: Ten independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype (OR = 1.49, 95%CI = 1.19-1.86, = 0.0004). Such a significance was observed in the overdominant (OR = 1.27, 95%CI = 1.14-1.41, < 0.0001) and allele genetic models (OR = 1.43, 95%CI = 1.17-1.74, = 0.0005) as well. This finding was also valid in the Asian population.
Conclusions: Mutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8783703 | PMC |
| http://dx.doi.org/10.1155/2022/5507153 | DOI Listing |
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