The intensity of IP protection has traditionally been determined by assessing the criteria that need to be satisfied for the protection to be granted, as well as the scope of rights and limitations of those rights. The enforcement stage and the remedies available to right holders have for long been, if not neglected, then certainly treated with lesser attention. The rise of aggressive litigation strategies, especially in the field of patents, has brought the enforcement stage to the forefront of the discussion about the proper level of IP protection in general and patent law in particular. Injunctions provide particularly strong leverage at the enforcement stage, allowing patentees in some cases to obtain royalties that exceed the value of the protected inventions. The principle of proportionality can play an important role as a check on excessive litigation strategies by patentees. Flexibility, however, comes at the price of uncertainty and unpredictability as to the outcome of patent disputes. Therefore, it is crucial to apply proportionality in an orderly and structured manner. For that purpose, the article identifies a set of factors that may be helpful in applying proportionality in patent disputes. That set of factors is well grounded in the traditions of the laws of the EU Member States.
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http://dx.doi.org/10.1007/s40319-021-01139-6 | DOI Listing |
Int J Environ Res Public Health
December 2024
Department of Physical Education and Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece.
Background: Migrant construction workers involved in building infrastructure for mega-sporting events face elevated risks of illness and death. However, specific health outcomes for these workers have not been systematically reviewed, limiting opportunities to identify and address their challenges.
Methods: This study systematically reviewed health outcomes among migrant construction workers involved in mega-sporting events.
MethodsX
June 2025
School of Social Sciences, University of Tasmania, Tasmania 7005, Australia.
Researchers today face significant challenges reshaping the landscape of academic, government, and industry research due to the exponential growth of global research outputs and the advent of Generative Artificial Intelligence (GenAI). The annual increase in published works has made it difficult for traditional literature review and data analysis methods to keep pace, often rendering reviews outdated by the time of publication. In response, this methods article introduces a suite of new tools designed to automate a number of stages for systematic literature reviews.
View Article and Find Full Text PDFChem Biol Interact
January 2025
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address:
Prostate cancer, the second leading cause of cancer-related mortality in men, exhibits distinct metabolic reprogramming involving zinc and citrate metabolism. This study investigated whether targeting this unique metabolic profile could offer an effective therapeutic approach. A series of novel oxindole derivatives were synthesized and evaluated for their inhibitory effects on transcription factors (TFs) and antiproliferative activity across various cancer cell lines.
View Article and Find Full Text PDFPLoS One
January 2025
Volta Regional Health Directorate, Ghana Health Service, Ho, Volta Region, Ghana.
Background: Hepatitis B and C viral (HBV and HCV) infections are endemic in Ghana. Also, the National Policy on Viral Hepatitis stipulates that there is unreliable data, limited knowledge, and a deficiency in research on viral hepatitis, especially among some high-risk workers in the eastern part of the country. This study therefore assessed the knowledge level and occupational practices of street beauticians and barbers in the transmission of HBV and HCV in the Volta Region of Ghana.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Civil Engineering, Regional Water and Environmental Sanitation Centre, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ashanti, Ghana.
Access to safe sanitation facilities remains a critical public health concern, especially in rapidly urbanizing countries like Ghana. This study investigates the determinants of household toilet ownership among property owners in three urban districts in Ghana. Using a cross-sectional survey design, data were collected from 1,256 property owners selected through a multi-stage stratified sampling procedure.
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