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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786957 | PMC |
| http://dx.doi.org/10.1038/s41467-022-28115-z | DOI Listing |
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Enhancing Multispectral Breast Imaging Quality Through Frame Accumulation and Hybrid GA-CPSO Registration.
Bioengineering (Basel)
December 2024
Medical School, Faculty of Medicine, Tianjin University, Tianjin 300072, China.
Multispectral transmission imaging has emerged as a promising technique for imaging breast tissue with high resolution. However, the method encounters challenges such as low grayscale, noisy transmission images with weak signals, primarily due to the strong absorption and scattering of light in breast tissue. A common approach to improve the signal-to-noise ratio (SNR) and overall image quality is frame accumulation.
View Article and Find Full Text PDFMitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases.
medRxiv
December 2024
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA USA.
Background: Variants in the mitochondrial genome (mtDNA) cause a diverse collection of mitochondrial diseases and have extensive phenotypic overlap with Mendelian diseases encoded on the nuclear genome. The mtDNA is often not specifically evaluated in patients with suspected Mendelian disease, resulting in overlooked diagnostic variants.
Methods: Using dedicated pipelines to address the technical challenges posed by the mtDNA - circular genome, variant heteroplasmy, and nuclear misalignment - single nucleotide variants, small indels, and large mtDNA deletions were called from exome and genome sequencing data, in addition to RNA-sequencing when available.
AutoFOX: An automated cross-modal 3D fusion framework of coronary X-ray angiography and OCT.
Med Image Anal
December 2024
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China; Department of Cardiovascular Medicine, University of Oxford, OX39DU, UK. Electronic address:
Article Synopsis
- Coronary artery disease (CAD) is a major global health issue, and combining coronary X-ray angiography (XA) with optical coherence tomography (OCT) can enhance diagnosis and treatment by providing detailed images of coronary anatomy and plaque structure.
- The new framework, AutoFOX, employs a deep learning model called TransCAN to accurately align 3D vascular images, achieving impressive alignment precision, especially at critical anatomical points.
- AutoFOX also includes innovative methods for reconstructing side branches and utilizes a diverse dataset for validation, demonstrating strong accuracy and reliability in assessing bifurcation lesions, which is essential for improving CAD management and procedures.
Pleiotropic Associations with Alzheimer's Disease and Physical Activity: Sex Differences and the Effects of Environment.
Int J Mol Sci
November 2024
Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.
Physical activity (PA) is a modifiable factor in mitigating/preventing Alzheimer's disease (AD). It is crucial to identify the conditions under which PA's effects on AD risk would be beneficial. This study aims to gain insights into pleiotropic predisposition to AD and PA within and across sexes and environmental effects.
View Article and Find Full Text PDFIn addition to laser frequency sweep nonlinearity, sensing point misalignment caused by a random laser frequency sweep range (LFSR) is a key factor limiting the sensing performance of the optical frequency domain reflectometer (OFDR). Here we propose a synchronous equal frequency resampling (SEFR) method for the first time to our knowledge to simultaneously compensate both the random LFSR and sweep nonlinearity. A new linear frequency sequence has been constructed to perform signal resampling of both the reference and measurement stages, which eliminates the sensing point misalignment and nonlinear frequency interval at the same time.
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