AI Article Synopsis
- A novel biosensor using an AlGaAs/GaAs HEMT is designed for detecting prostate-specific antigen (PSA), featuring a unique zinc oxide nanotetrapod structure that enhances the detection area.
- The 3D concave design of the detection pad increases the number of sites for biological modifications, improving both detection scope and sensitivity compared to traditional flat surfaces.
- The biosensor shows reliable performance with a linear current/voltage response for PSA levels ranging from 5 fg/ml to 5 ng/ml, achieving a sensitivity variation of approximately 1.3% per decade.
Article Abstract
In this study, separative extended-gate AlGaAs/GaAs high electron mobility transistor (HEMT) biosensor is proposed for prostate-specific antigen (PSA) detection. Zinc oxide nanotetrapods (T-ZnO) with a four-leg structure is introduced onto the sensing pad to form a three-dimensional (3D) and concave detection front. Compared with common plane front, the elaborately-designed-3D and concave detection front can offer more biological modification sites and decrease the Debye volume, resultantly improving both the detection scope and sensitivity. Anti-PSA probes can be fixed at any sites of T-ZnO via a chemical bio-functionalization method, which facilitates better detection performance by comparison with a physical modification scheme. On the other hand, the T-ZnO nanostructures with the four-leg configuration are capable of releasing the stress and erosion effect of the solution on the plane Au film, contributing to a great improvement in the reliability of the biosensors. The optimized biosensors with chemical bio-functionalized T-ZnO detection front demonstrate good linear current/voltage response to label-free PSA target in the concentration range from 5 fg/ml~5 ng/ml and a sensitivity variation ~ 1.3% dec.
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| http://dx.doi.org/10.1016/j.jpba.2022.114597 | DOI Listing |
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