AI Article Synopsis
- The study investigated how different doses of fluoxetine in food affect juvenile rainbow trout, focusing on their morphology, hematology, biochemistry, and oxidative stress.* -
- Significant changes were observed in the fish's immune response, with an increased neutrophil/lymphocyte ratio and decreased lymphocyte count, alongside reduced detoxifying enzyme activity in the liver and kidney.* -
- Histopathological analysis showed damage to the kidney's proximal tubules, confirming that fluoxetine has notable adverse effects on the health of rainbow trout.*
Article Abstract
The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, hematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in hematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.
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| http://dx.doi.org/10.1016/j.etap.2022.103818 | DOI Listing |
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