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IgG4-related disease (IgG4-RD) is a systemic inflammatory condition characterized by tissue infiltration with IgG4-positive plasma cells and a tendency to form mass-like lesions in various organs. IgG4-related sinusitis, although a relatively rare manifestation of IgG4-RD, significantly impacts the paranasal sinuses. A 52-year-old man presented with persistent rhinorrhea, nasal obstruction, and headaches.

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Multiple intrahepatic artery aneurysms during the treatment for IgG4-related sclerosing cholangitis: A case report.

World J Hepatol

December 2024

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.

Article Synopsis
  • The case report discusses a 64-year-old woman with IgG4-related sclerosing cholangitis who developed multiple intrahepatic artery aneurysms while on treatment.
  • Emergency procedures successfully treated the aneurysms, resolving her symptoms and stabilizing her condition.
  • The report highlights that hepatic artery aneurysms can be serious complications in patients with IgG4-SC, indicating a need for vigilant monitoring.
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Autoimmune inner ear disease (AIED) is a rare condition characterized by immune-mediated damage to the inner ear, leading to progressive sensorineural hearing loss (SNHL) and vestibular symptoms such as vertigo and tinnitus. This study investigates the pathogenesis and therapeutic strategies for AIED through the analysis of three cases with different underlying autoimmune disorders: rheumatoid arthritis, relapsing polychondritis, and IgG4-related disease. The etiology of AIED involves complex immunopathological mechanisms, including molecular mimicry and the "bystander effect," with specific autoantibodies, such as those against heat shock protein 70 (HSP70), playing a potential role in cochlear damage.

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Successful rituximab treatment in IgG4-related coronary periarteritis: a case-based review.

Rheumatol Int

December 2024

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is an immune-mediated disorder characterized by elevated serum IgG4 levels and the enlargement and fibrosis of organs. As a rare manifestation, coronary arteries can be affected by IgG4-RD as coronary periarteritis, leading to serious complications such as stenosis or aneurysm. Although coronary periarteritis poses a life-threatening condition, optimal treatment strategies remain unclear due to its extreme rarity.

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Preserflo MicroShunt (PMS) implantation is a minimally invasive surgical procedure for treating glaucoma. Postoperative hypotony, a common complication of PMS implantation, can be prevented and treated with 10-0 nylon insertion. In this report, we present a case of postoperative hypotony following PMS implantation that was treated with intraluminal insertion of 9-0 nylon.

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