AI Article Synopsis
- The study investigates how platelet levels and the platelet to mean platelet volume (PLT/MPV) ratio affect the prognosis of advanced esophageal squamous cell carcinoma (ESCC) patients treated with apatinib.
- Retrospective analysis of 80 advanced ESCC patients showed that higher PLT and PLT/MPV ratios correlated with better progression-free survival (PFS), with significant findings (156 days vs. 80 days and 157 days vs. 85 days, respectively).
- Multivariate analysis indicated that a high pretreatment PLT/MPV ratio was an independent predictor of longer PFS, suggesting that these blood parameters may help assess treatment outcomes in patients receiving later lines of apatinib therapy
Article Abstract
Apatinib has a certain efficacy for advanced esophageal squamous cell carcinoma (ESCC). This study aimed to investigate the prognostic significance of platelet (PLT) and platelet to mean platelet volume (PLT/MPV) ratio for advanced ESCC patients with apatinib second-line or late-line treatment. A retrospective study included 80 patients with advanced ESCC who received Apatinib ≥ 2 lines targeted therapy. We collected baseline clinical characteristics and blood parameters from the patients. Kaplan-Meier plots and univariate and multivariate analysis were used to find the factors related to progression-free survival (PFS). The optimal cut-off values of PLT and PLT/MPV ratio were determined by X-tile software. Kaplan-Meier analysis demonstrated that patients in the high PLT group had better PFS than those in the low PLT group (156 d vs 80 d, <.001), and patients in the high PLT/MPV ratio group had better PFS than those in low PLT/MPV ratio group (157 d vs 85 d, <.001). Univariate analysis revealed pretreatment PLT and PLT/MPV ratio were significantly correlated with PFS. Multivariate analysis revealed high levels of pretreatment PLT/MPV ratio was an independent predictor of longer PFS (HR: 0.257, 95% CI: 0.089-0.743, = .012). High levels of baseline PLT and PLT/MPV may indicate a better prognosis in apatinib ≥ 2 lines treatment for advanced ESCC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8808027 | PMC |
| http://dx.doi.org/10.1177/15330338211072974 | DOI Listing |
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