Roles of BMI1 in the Initiation, Progression, and Treatment of Hepatocellular Carcinoma.

Liver cancer has high rates of morbidity and mortality, and its treatment is a global health challenge. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancer cases. B-lymphoma Mo-MLV insertion region 1 () has been identified as a proto-oncogene, which contributes to the initiation and progression of many malignant tumors. expression is upregulated in HCC, and it influences the occurrence and development of HCC by various mechanisms, such as the INK4a/ARF locus, NF-κB signaling pathway, and PTEN/PI3K/AKT signaling pathway. In addition, the expression of is related to prognosis and recurrence of HCC. Hence, there is clear evidence that is a novel and valid therapeutic target for HCC. Accordingly, the development of therapeutic strategies targeting has been a focus of recent research, providing new directions for HCC treatment. This review summarizes the role of in the occurrence and treatment of HCC, which will provide a basis for using as a potential target for the development of therapeutic strategies for HCC.