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Exploring the anti‑inflammatory activity of boron compounds through the miR‑21/PTEN/AKT pathway in cecal ligation and puncture‑induced sepsis.
Mol Med Rep
February 2025
Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
The present study investigated the impact of boric acid (BA) and borax (BX) on markers of inflammation and modifications in miR‑21/PTEN/AKT pathway genes in the liver and kidney tissues of Sprague Dawley male rats with sepsis induced by cecal ligation and puncture (CLP). A total of 60 male Sprague Dawley rats were randomly divided into 6 groups, each containing 10 animals as follows: Control, CLP (where the model was created), 20 mg/kg BX (CLP + BX1), 40 mg/kg BX (CLP + BX2), 20 mg/kg BA (CLP + BA1) and 40 mg/kg BA (CLP + BA2). Liver and kidney tissues were analyzed for histopathological changes, immunopositivity for tumor necrosis factor‑α, interleukin (IL)‑6 and IL‑10, and gene expression of microRNA‑21 (miR‑21), phosphatase and tensin homolog (PTEN) and AKT.
View Article and Find Full Text PDF[G. A. Miterev, the director of the Erisman Central Research Sanitary Institute].
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med
November 2024
N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia,
Georgy Andreyevich Miterev, after leaving the post of Minister of Health of the USSR, worked as Director of the F. F. Erisman Central Research Sanitary Institute from 1947 to 1954.
View Article and Find Full Text PDFCombining the induced pluripotent stem cell (iPSC) technology with chimeric antigen receptor (CAR)-based immunotherapy: recent advances, challenges, and future prospects.
Front Cell Dev Biol
November 2024
Hematology and blood transfusion science department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
After experiencing many ups and downs, chimeric antigen receptor (CAR)-T cell therapy has reached a milestone as an anti-cancer method, as evidenced by the increasing number of clinical trials and approved products. Nonetheless, there is a real need to optimize CAR-T cell therapy and overcome its existing limitations. The importance of cellular starting material for generating CAR-T cells is undeniable, as the current personalized manufacturing approach is the main roadblock to providing a fast, affordable, and standard treatment for patients.
View Article and Find Full Text PDFArticle Synopsis
- - The study conducted a meta-analysis on the prevalence and levels of Ochratoxin A (OTA) in beer, reviewing 30 papers with a total of 70 data reports, which revealed a combined OTA prevalence of 50.60%.
- - The countries with the highest OTA levels in beer were identified as South Africa, Slovakia, Portugal, Tunisia, and Greece, with South Africa having the highest concentration at 1170.750 μg/L.
- - While the risk of non-carcinogenic effects from OTA in beer is deemed acceptable in most countries, it is advised to improve the quality control of raw materials like barley, especially in South Africa and Slovakia.
Carbon monoxide inhalation as a potential aid to enhance aerobic endurance.
Med Gas Res
March 2025
Department of Sports Medicine and Medical Rehabilitation, Sechenov First Moscow State Medical University of the Ministry of Health of the Russia Federation, Moscow, Russia.
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