The Interaction Between N-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers.

N-methyladenosine (mA) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA mA modification process by affecting the expression of mA-related enzymes. The interaction between mA modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of mA and non-coding RNAs in gastrointestinal tract cancers.