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A systematic review and meta-analysis on the efficacy of Compound Kushen Injection in 3 kinds of digestive tract tumor. | LitMetric

AI Article Synopsis

  • Chemotherapy is commonly used for advanced digestive tract cancer but often leads to severe side effects; Compound Kushen Injection (CKI) is a Chinese herbal remedy that may enhance chemotherapy effectiveness and lessen its negative impacts.
  • A systematic review and meta-analysis were conducted on clinical randomized controlled trials of CKI used alongside chemotherapy from January 2000 to September 2021, involving 1,080 participants.
  • The findings indicated that CKI improved treatment efficacy, increased median survival times, enhanced immune markers (CD3 and CD4 levels), lowered certain tumor markers (CEA and CA199), and decreased occurrences of chemotherapy-related adverse effects like leukopenia and thrombocytopenia.

Article Abstract

Background: Chemotherapy has become the main means to prolong the life of patients with advanced digestive tract cancer; however, it is associated with serious toxicity and side effects. Compound Kushen Injection (CKI) is a pure Chinese herbal preparation, which can assist chemotherapy, inhibit tumor cell proliferation, and reduce adverse reactions of chemotherapy. In this study, we systematically evaluated reports of CKI as an adjuvant to chemotherapeutic treatment of digestive tract cancer in recent years and provided evidence for clinical diagnosis and treatment.

Methods: The databases of PubMed, Chinese Biomedical Literature (CBM), China National Knowledge Infrastructure (CNKI) and Web Of Science were searched for clinical randomized controlled trials (RCTs) related to adjuvant chemotherapy with CKI in the treatment of advanced gastrointestinal tumors published from January 2000 to September 2021. After screening the qualified literatures, RevMan 5.4 software was used to evaluate the bias of the included literatures and perform meta-analysis.

Results: A total of 12 articles were included in the selection, incorporating 1080 study participants in all; meta-analysis results showed that application of the CKI in the process of chemotherapy for digestive tract tumors could improve the efficacy [odds ratio (OR) =3.11; 95% confidence interval (CI): 2.26 to 4.47, Z=7.00, P<0.00001], increase the patients' median survival time (months) (OR =3.00; 95% CI: 1.47 to 4.52, Z=3.84, P=0.0001), increase the level of CD3 [mean difference (MD) =4.11; 95% CI: 3.24 to 4.98], CD4 level (MD =8.24; 95% CI: 3.72 to 12.76), reduce the CD8 level (MD =-5.42; 95% CI: -8.09 to -2.76), reduce the tumor markers carcinoembryonic antigen (CEA; MD =-14.26; 95% CI: -14.81 to -13.71), CA199 (MD =-138.87; 95% CI: -143.21 to -132.52), and reduce the adverse reactions of chemotherapy: leukopenia (OR =0.28; 95% CI: 0.19 to 0.43), thrombocytopenia (OR =0.38; 95% CI: 0.24 to 061), decreased hemoglobin (OR =0.55; 95% CI: 0.31 to 0.98), and nausea and vomiting symptoms (OR =0.35; 95% CI: 0.24 to 0.53).

Discussion: Adjuvant chemotherapy with CKI in the treatment of digestive tract tumors can effectively improve the symptoms of patients, improve immunity, reduce the level of serum tumor markers, improve efficacy, and reduce toxic and side effects.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748064PMC
http://dx.doi.org/10.21037/jgo-21-774DOI Listing

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