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Development and Validation of a Novel Prognostic Score Based on Thrombotic and Inflammatory Biomarkers for Predicting 28-Day Adverse Outcomes in Patients with Acute Pancreatitis. | LitMetric

AI Article Synopsis

  • Acute pancreatitis (AP) is a serious illness influenced by thrombosis and inflammation, leading to high rates of morbidity and mortality.
  • The study aims to create and validate a new scoring system called the thrombo-inflammatory prognostic score (TIPS), which uses prothrombin time (PT) and interleukin-6 (IL-6) to predict negative outcomes after 28 days in AP patients.
  • Results showed that TIPS is a reliable predictor of 28-day mortality and other severe outcomes, demonstrating performance comparable to established scoring systems.

Article Abstract

Background: Acute pancreatitis (AP) is a multifactorial disease that is associated with substantial morbidity and mortality. Thrombosis and inflammation are involved in the development and progression of AP.

Aim: To develop and validate a novel and simple scoring system for predicting 28-day adverse outcomes in AP patients based on a thrombotic and an inflammatory biomarker.

Methods: A single-center, retrospective cohort study was used to establish the new scoring system (thrombo-inflammatory prognostic score; TIPS), and another study was used to verify it. The study end points were 28-day mortality, requirement for mechanical ventilation (MV), persistent organ failure (POF), and admission to the intensive care unit (AICU). Receiver operating characteristic (ROC) curves was drawn to validate the predictive value of the TIPS. The performance of the TIPS was compared with that of conventional predictive scoring systems. Logistic regression models were used to investigate the relationship between the TIPS and the different end points.

Results: Among 440 patients with AP in the derivation group, 27 patients died within the 28-day follow-up period. Prothrombin time (PT) and interleukin-6 (IL-6) were used to calculate the TIPS. The TIPS (AUC=0.843) showed a performance comparable to that of the more established APACHE II (AUC=0.841), SOFA (AUC=0.797), BISAP (AUC=0.762), and Balthazar CT (AUC=0.655) in predicting 28-day mortality in AP. The 28-day mortality and the incidence of MV, POF, and AICU were significantly higher among patients with a higher TIPS (<0.001). The results of logistic regression analyses indicated that the TIPS was independently associated with the risks of 28-day mortality, AICU, MV and POF.

Conclusion: The TIPS can enable prediction of 28-day adverse clinical outcomes with AP patients in the ED.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769056PMC
http://dx.doi.org/10.2147/JIR.S344446DOI Listing

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