Microarray analysis to explore the effect of isoforms in a pancreatic pre-tumor cell model.

World J Gastroenterol

The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China.

Published: December 2021

expression was significantly lower in tumor samples than in corresponding normal samples. expression was significantly positively related to the infiltration levels of T cells, dendritic cells (DCs), immature DCs, cytotoxic cells, Tfh cells, mast cells, B cells, Th1 cells, natural killer (NK) cells, pDCs, neutrophils, and T helper cells (Spearman correlation coefficient > 0.5, < 0.001) and negatively correlated with the infiltration level of NK CD56bright cells. In addition, pancreatic hTERT-HPNE cells treated with three diverse isoforms exhibited changes mainly in the regulation of the epithelial-mesenchymal transition activation pathway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704271PMC
http://dx.doi.org/10.3748/wjg.v27.i47.8194DOI Listing

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