Background: Taste perception is an important factor in sustaining human life. Impairment of taste is one of the important features of oral submucous fibrosis (OSMF), and it has not received much attention, owing to limited research work in the field. Therefore, the present study was conducted to determine taste alteration in OSMF patients.
Materials And Methods: A total of 200 participants, both males and females with the age range of 20 years to 55 years, were included in the study. Four basic tastants (i.e., sweet, salt, sour, and bitter) were prepared as follows: sucrose for sweet (0.1-1.0 mol/l), sodium chloride for salty (0.01-1.0 mol/l), citric acid for sour (0.320-0.032 mol/l), and quinine sulfate for bitter (0.01-1.0 mol/l) and full mouth rinse test was performed for a complete taste response examination, after which punch biopsy was taken from buccal mucosa to determine histopathological staging. The data obtained were tabulated and analyzed by the Pearson Chi-square test; < 0.05 was considered statistically significant.
Results: The overall results suggested that there was a significant alteration of taste. The sweet taste was altered followed by salty and bitter was least affected.
Conclusion: The study points out at the significance of alteration in taste perception is OSMF patients related to sweet, salt, sour, and bitter taste by using physiological stimuli tastants.
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http://dx.doi.org/10.4103/ccd.ccd_664_20 | DOI Listing |
Neuroimage
January 2025
Laboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Introduction: The beneficial effects of substituting sugar with non-caloric sweeteners (NCSs) remain uncertain due to the mismatch between their rewarding sweet taste and lack of energy content. Functional magnetic resonance imaging (fMRI) studies indicate an influence of cognitive processes (e.g.
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January 2025
Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:
Background/purpose: Taste impairment is a common yet complex toxicity of head and neck cancer (HNC) radiotherapy treatment that may affect quality of life of survivors. This study aimed to predict acute and late taste impairment using taste bud bearing tongue mucosa as a new taste-specific organ-at-risk compared to full oral cavity as identified in previous studies.
Materials/methods: Included HNC patients were treated with curative radiotherapy between 2007 and 2022.
Food Chem
January 2025
Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, İstanbul 34210, Türkiye; Health Biotechnology Joint Research and Application Center of Excellence, Istanbul 34903, Türkiye. Electronic address:
Umami taste properties of a novel octameric peptide KADEDSLA and its mutants p.A2G, p.D5E, and BMP (KGDEESLA, beef meaty peptide) were assessed by molecular docking, and molecular dynamics (MD) (>1 μsec), MM-PBSA, and Mutational Affinity Prediction (MAP) methods.
View Article and Find Full Text PDFPLoS Biol
January 2025
Department of Biology, University of Fribourg, Fribourg, Switzerland.
J Agric Food Chem
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Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China.
Steviol glycosides (SGs) are highly valued for their sweetness, safety, and zero calories, but their bitter taste and low solubility limit their application. Modifying glycosyl units is a promising strategy to improve sensory qualities. In this study, we identified the enzyme UGT94E13 through phylogenetic analysis and enzyme screening, which catalyzes the glycosylation of rebaudioside M2 (Reb M2) at the C-13 position, producing the novel β-1,6--glycosylated product rebaudioside M9 (Reb M9).
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