extends lifespan through activation of DAF-16-mediated antioxidant pathway in .

bacteria, which are widely used as fermented starter for dairy production, exert various beneficial health effects. Nevertheless, even though pro-longevity effects of various probiotics have been reported, no report has described effects on longevity. This study was conducted to evaluate effects on lifespan extension and to elucidate the -mediated longevity mechanism using worms as a model animal. They were fed standard food ( OP50) or from the young adult stage. Feeding with , compared to OP50, to extend the lifespan, reduced lipofuscin accumulation, and maintain vigorous locomotion. Feeding with did not alter the worm growth curve or the offspring number, indicating that the -mediated lifespan extension is not attributable to caloric restriction. The qRT-PCR data showed that increased the expression of and some of its downstream antioxidant genes. Furthermore, the pro-longevity effects of were decreased in loss-of-function mutant of . Results show that extends the lifespan of through DAF-16-mediated antioxidant pathway activation.