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| http://dx.doi.org/10.4103/ijd.ijd_1_21 | DOI Listing |
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Chronic Pruritus: A Review.
JAMA
June 2024
Miami Itch Center, Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
Article Synopsis
- - Chronic pruritus, or long-term itch lasting 6 weeks or more, affects about 22% of people, leading to poor sleep and decreased quality of life, though it represents only 1% of doctor visits.
- - The condition can be classified into inflammatory (60% of cases), neuropathic (25%), or other causes (15%), with common inflammatory triggers being eczema and psoriasis, while neuropathic issues may arise from nerve dysfunction.
- - Diagnosis often involves thorough history-taking and lab tests, with initial treatments typically being topical anti-inflammatory medications; if these fail, referral to a specialist or systemic treatments may be necessary.
β-Lactoglobulin variants as potential carriers of pramoxine: Comprehensive structural and biophysical studies.
J Mol Recognit
October 2023
Faculty of Biochemistry, Biophysics and Biotechnology, Department of Physical Biochemistry, Jagiellonian University, Kraków, Poland.
β-Lactoglobulin (BLG) is a member of the lipocalin family. As other proteins from this group, BLG can be modified to bind specifically compounds of medical interests. The aim of this study was to evaluate the role of two mutations, L39Y and L58F, in the binding of topical anesthetic pramoxine (PRM) to β-lactoglobulin.
View Article and Find Full Text PDFBed Bug Infestation: An Updated Review.
Curr Pediatr Rev
July 2024
Department of Paediatrics, The Chinese University of Hong Kong.
Article Synopsis
- - Bed bug infestations have surged globally, necessitating awareness and proper identification for effective treatment and eradication.
- - Bed bug bites are usually painless, presenting as itchy, red bumps that can appear in clusters or a linear pattern, with specific features suggesting bed bug activity.
- - Treatment is mainly symptomatic, involving antihistamines and topical corticosteroids, alongside integrated pest management strategies that include cleaning, monitoring, and both nonchemical and chemical interventions for eradication.
Topical Pramoxine in Chronic Pruritus: Where do We Stand?
Indian J Dermatol
January 2021
Department of Dermatology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Prescription and over-the-counter topical anesthetics are commonly used. Although allergy to amide and ester anesthetics is known, little has been reported on the nonamide, nonester pramoxine (pramocaine). This article briefly reviews allergy to topical anesthetics, provides detailed information on pramoxine, and describes characteristics of multiple patients with positive, relevant reactions to pramoxine.
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