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Fractures in the femoral neck are a common occurrence in individuals with osteoporosis. Many mouse models have been developed to assess disease states and therapies, with biomechanical testing as a primary outcome measure. However, traditional biomechanical testing focuses on torsion or bending tests applied to the midshaft of the long bones. This is not typically the site of high-risk fractures in osteoporotic individuals. Therefore, a biomechanical testing protocol was developed that tests the femoral necks of murine femurs in cantilever bending loading to replicate better the types of fractures experienced by osteoporosis patients. Since the biomechanical outcomes are highly dependent on the flexural loading direction relative to the femoral neck, 3D printed guides were created to maintain a femoral shaft at an angle of 20° relative to the loading direction. The new protocol streamlined the testing by reducing variability in alignment (21.6° ± 1.5°, COV = 7.1%, n = 20) and improved reproducibility in the measured biomechanical outcomes (average COV = 26.7%). The new approach using the 3D printed guides for reliable specimen alignment improves rigor and reproducibility by reducing the measurement errors due to specimen misalignment, which should minimize sample sizes in mouse studies of osteoporosis.
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http://dx.doi.org/10.3791/63394 | DOI Listing |
Injury
February 2025
Department of Arthritis, Affiliated Hospital of Shandong Second Medical University, Weifang, 261031, PR China. Electronic address:
Objective: This study aimed to identify the optimal position for the femoral neck system (FNS) device when fixing Pauwels III #NOF, by analyzing the mechanical stability and stress distribution of FNS at different screw placement positions for the fixation of Pauwels III femoral neck fractures.
Methods: We employed finite element analysis to create a 3D model of a Pauwels type III femoral neck fracture. Six models were designed, each with varied FNS screw placement positions.
Mov Ecol
March 2025
Department of Entomology, The Volcani Center, Rishon LeTsiyon, Israel.
In a chemosensing system, the local olfactory environment experienced by a foraging organism is defined as an odorscape. Using the nocturnal pink bollworm moth (Pectinophora gossypiella), we tested the combined effect of three biophysical aspects in its immediate odorscape to shed light on the coupling effects of biotic and abiotic factors on navigation performances of a nocturnal forager: i) the quality of the pheromone source, ii) the pheromone availability, and iii) the airflow characteristics. The navigation performance of the males was investigated using a wind tunnel assay equipped with 3D infrared high-speed cameras.
View Article and Find Full Text PDFBMC Musculoskelet Disord
March 2025
Department of Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Würzburg, Oberdürrbacherstraße 6, 97080, Würzburg, Germany.
Background: Usually, comminuted fractures contain fragments that are too small for fixation with Kirschner (K)-wires or screws. For those bony or osteochondral fragments, a bone adhesive would be desirable to, for example, enable easy anatomic reduction, avoid discarding of the fragments, and enable temporary fixation to visualize reduction before definitive osteosynthesis is performed. Most of the currently available bone adhesives have shortcomings, such as cytotoxicity, lack of resorbability, and inadequate mechanical properties.
View Article and Find Full Text PDFScand J Med Sci Sports
March 2025
Univ Savoie Mont Blanc, Interuniversity Laboratory of Human Movement Sciences, Chambéry, EA, France.
We investigate the contribution of isometric rate of torque development (RTD) and maximal voluntary torque (MVT) to the dynamic force production capacities of knee extensors obtained from the torque-velocity (TV) relationship, that is, the theoretical maximal velocity (V), torque (T), and maximal power (P). Single-leg knee extensors were tested in 64 young adults (31 females). RTD and root mean square (RMS) of electromyographic signals from the knee extensors were recorded during isometric and incremental load dynamic (nonisokinetic) contractions.
View Article and Find Full Text PDFArthroscopy
March 2025
Sports Medicine Center, The Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot, Inner Mongolia, China. Electronic address:
Purpose: To investigate the biomechanical efficacy of the reverse suture anchor (RSA) technique compared with the transtibial pull-out (TP) and suture anchor (SA) techniques using in vitro porcine knee models of PMMRTs.
Methods: 32 fresh frozen porcine tibiae with medial meniscus intact were randomly assigned to four groups (eight specimens each). A standardized posterior medial meniscus root tear (PMMRT) was established in 24 specimens.
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