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Background: Studies have shown that the prevalence of all-variants Alzheimer's disease (AD) and frontotemporal dementia (FTD) both increase with age, even before the age of 65. However, it is not known whether their different clinical presentations all increase in prevalence with age in the same way.
Methods: We studied the prevalence of the different clinical presentations of young-onset AD and FTD by 5-year age groups in a population-based study identifying all dementia patients with a diagnosis of AD and FTD and symptoms onset before age 65 in the Modena province, Italy.
Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias.
Acta Neuropathol Commun
February 2024
Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Article Synopsis
- Pick's disease (PiD) is a type of tauopathy linked to frontotemporal lobar degeneration, manifesting in dementia syndromes like primary progressive aphasia (PPA) and behavioral variant frontotemporal dementia (bvFTD).
- The study examined brain distributions of Pick bodies in cases of bvFTD and PPA using brain tissue samples, specifically targeting areas such as the middle frontal gyrus and anterior temporal lobe for pathology.
- Findings showed that bvFTD had higher densities of Pick bodies in the frontal region, while PPA showed more in the temporal lobe, with both disorders exhibiting significant hippocampal pathology that did not align with neocortical findings.
[Behavioral Variant of Frontotemporal Dementia: A Case Report of a 54-Year-Old Female Patient].
Neuropsychopharmacol Hung
December 2023
Észak-Pesti Centrumkórház-Honvédkórház Pszichiátriai osztály.
Frontotemporal dementia is a neurodegenerative disease characterized by atrophy of the frontal and temporal lobes of the brain, and it is believed to primarily develop based on genetic factors. Its initial symptoms can appear relatively early, even between the ages of 40-50, affecting approximately 15-22 individuals out of 100,000 annually. The disease manifests in various forms, categorized into behavioral, aphasic, and motor variants due to its diverse presentations.
View Article and Find Full Text PDFAssessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task.
Cortex
February 2024
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA. Electronic address:
Article Synopsis
- The study explores the impact of Primary Progressive Aphasia (PPA) variants—nonfluent/agrammatic (nfvPPA), logopenic (lvPPA), and semantic (svPPA)—on non-verbal cognitive abilities, specifically processing speed, using a non-verbal task called Match.
- Results show that lvPPA and nfvPPA patients performed worse on the task compared to healthy controls and svPPA patients.
- Neuroimaging revealed that poorer task performance correlated with reduced gray and white matter volumes in key brain regions associated with processing speed and executive control.
Speech and language markers of neurodegeneration: a call for global equity.
Brain
December 2023
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143, USA.
In the field of neurodegeneration, speech and language assessments are useful for diagnosing aphasic syndromes and for characterizing other disorders. As a complement to classic tests, scalable and low-cost digital tools can capture relevant anomalies automatically, potentially supporting the quest for globally equitable markers of brain health. However, this promise remains unfulfilled due to limited linguistic diversity in scientific works and clinical instruments.
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