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Purpose: To identify the usefulness of Four Square Step Test (FSST) in discriminating balance control in non-frail, pre-frail, and frail community-dwelling older adults.
Design: Cross-sectional study.
Methods: Cross- sectional study conducted in specialized outpatient geriatric care settings. One hundred and fifty-six consecutive patients without severe cognitive impairment and who could walk were included. We classified participants as non-frail, pre-frail, and frail using the Fried frailty phenotype. FSST was assessed by measuring the time (seconds) participants took to step into each of the four quadrants formed by four sticks arranged on the floor (clockwise and counterclockwise as quickly as possible) without knocking the sticks.
Results: Of all participants, 36% were non-frail, 37% pre-frail, and 27% frail. Frail and pre-frail older adults took significantly more time to execute the FSST (23.1, 95% CI 18.8-27.4; p < 0.001 and 17.9; 95% CI 14.3-21.5; p = 0.003, respectively) compared to with non-frail (11.6, 95% CI 11.0-12.3). Frail and pre-frail older adults were not significantly different (p = 0.058). Most participants who failed to perform the test were frail (n = 15; 36%), followed by pre-frail (n = 7; 12%) and non-frail (n = 2; 3.5%).
Discussion: Our results showed that pre-frail and frail older adults had poorer performance in FSST when compared to non-frail older adults. It is important to use instruments that allow early identification, especially of pre-frail older adults, as they are still at the beginning of the frailty process when the control and reversal of adverse outcomes are promising. Failing the test could be a sign of mobility loss, particularly due to balance and cognitive problems. Clinical practitioners could use the test to compare individual's performance attending rehabilitation programs over different periods of time.
Conclusion: FSST is a useful and safe measure of dynamic balance and discriminates frail and pre-frail from non-frail older adults. Further diagnostic accuracy studies should be conducted to determine FSST predictive capacity.
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http://dx.doi.org/10.1016/j.exger.2022.111699 | DOI Listing |
Front Public Health
December 2024
School of Medicine and Health Management, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Objective: Mental health has become a widely concerned topic worldwide. However, the impact and mechanism of positive activities on mental health still needed to be explored. This study aimed to apply the positive-activity model to investigate the effect of participation in positive activities on mental health and the mediating role of positive emotion.
View Article and Find Full Text PDFVaccine X
January 2025
Department of Chemical-Pharmaceutical and Biomolecular Technologies, Faculty of Pharmacy, Catholic University "Our Lady of Good Counsel", Tirana, Albania.
Introduction: Human papillomavirus (HPV) infection is a widespread skin-to-skin transmitted infection that poses a global health concern. Although Albania faced prior challenges, it has recently introduced a quadrivalent recombinant HPV vaccine, a critical step in preventing cervical cancer among young women. This study aims to identify potential gaps in knowledge and attitudes among Albanian women regarding cervical cancer and HPV infection, as well as provide insights into the effectiveness of the national primary prevention program.
View Article and Find Full Text PDFChemistry
December 2024
Universidad Complutense de Madrid, Organic Chemistry, SPAIN.
The synthesis and characterization of novel compounds (5-8) as mimetics of [FeFe]-hydrogenase, combining two distinct systems capable of participating in hydrogen evolution reactions (HER): the [(μ-adt)Fe2(CO)6] fragment and M-salen complexes (salen = N,N'-bis(salicylidene)ethylenediamine) (M = Zn, Ni, Fe, Mn), is reported. These complexes were synthesized in high yields via a three-step procedure from N,N'-bis(4-R-salicylidene)ethanediamine) 4 [R = Fe2(CO)6(μ-SCH2)2COCH2O)]. Structural analysis through spectroscopic, spectrometric, and computational (DFT) methods confirmed distorted tetrahedral and square-planar geometries for Zn-salen and Ni-salen complexes (5 and 6) respectively, while complexes Fe-salen 7 and Mn-salen 8 exhibit square-based pyramidal structures typical of Fe(III) and Mn(III) high-spin salen-complexes.
View Article and Find Full Text PDFJ Pathol Inform
December 2024
Computer Imaging and Medical Application Laboratory, Universidad Nacional de Colombia, Bogotá 111321, Colombia.
Cytomorphology evaluation of bone marrow cell is the initial step to diagnose different hematological diseases. This assessment is still manually performed by trained specialists, who may be a bottleneck within the clinical process. Deep learning algorithms are a promising approach to automate this bone marrow cell evaluation.
View Article and Find Full Text PDFTalanta
December 2024
São Carlos Institute of Chemistry, University of São Paulo, Av. João Dagnone, 1100, 13566-590, São Carlos, SP, Brazil. Electronic address:
This study reports the development and implementation of a straightforward, rapid, and cost-effective voltammetric technique for piroxicam (PIR) detection at nanomolar concentrations in biological and environmental samples. The method involved the use of a screen-printed electrode (SPE) enhanced with a combination of Printex L6 carbon (PL6C) and polyaniline-based activated carbon (PAC) on a chitosan film crosslinked with epichlorohydrin (CTS:EPH). The detection was carried out using square-wave adsorptive anodic stripping voltammetry (SWAdASV) in a 0.
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