AI Article Synopsis
- The study focuses on the 10-meter walk/run test (10MWRT) in young individuals with spinal muscular atrophy (SMA) to track changes in walking speed over time and its association with various factors.
- It examined untreated participants aged 2 to 21 years to establish how 10MWRT time relates to age, SMA type, SMN2 copy number, and body weight.
- The results indicate that walking speed improves in early childhood, stabilizes for a short period, and then declines in later teenage years, providing important insights for future treatment interpretations.
Article Abstract
As trials and treatments for spinal muscular atrophy (SMA) rapidly evolve, understanding the natural history and potential utility of the 10-meter walk/run test (10MWRT) in ambulant individuals is critical. Study aims were to: 1) establish change over time and across age for 10MWRT time in an untreated natural history cohort of young, ambulatory participants with SMA and 2) identify relations between 10MWRT time and age, SMA type, SMN2 copy number and anthropometrics. Untreated individuals (n = 56) age 2 to 21 years who were enrolled in a long-term natural history study between 2005 and 2014 and met inclusion criteria were included. Linear mixed effects models were used to assess changes in 10MWRT time with age and associations with SMA type, SMN2 copy number, and body mass. SMA type 3b (versus 3a), SMN2 copy number 4 (versus 3) and lower body mass were associated with faster 10MWRT. 10MWRT performance improved between 3 and 8 years of age, was stable between 9 and 10, and gradually declined from 11 to 18. Findings provide the first longitudinal natural history report of 10MWRT time in young individuals with SMA and offer a critical foundation for interpreting childhood change in short distance walking speed with pharmacologic treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908436 | PMC |
| http://dx.doi.org/10.1016/j.nmd.2021.08.010 | DOI Listing |
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