Background: The overall survival rate of osteosarcoma (OS) patients has not been improved for 30 years, and the diagnosis and treatment of OS is still a critical issue. To improve OS treatment and prognosis, novel kinds of theranostic modalities are required. Molecular optical imaging and phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), are promising strategies for cancer theranostics that exhibit high imaging sensitivity as well as favorable therapeutic efficacy with minimal side effect. In this study, semiconducting polymer nanoparticles (SPN-PT) for OS-targeted PTT/PDT are designed and prepared, using a semiconducting polymer (PCPDTBT), providing fluorescent emission in the second near-infrared window (NIR-II, 1000 - 1700 nm) and photoacoustic (PA) signal in the first near-infrared window (NIR-I, 650 - 900 nm), served as the photosensitizer, and a polyethylene glycolylated (PEGylated) peptide PT, providing targeting ability to OS.
Results: The results showed that SPN-PT nanoparticles significantly accelerated OS-specific cellular uptake and enhanced therapeutic efficiency of PTT and PDT effects in OS cell lines and xenograft mouse models. SPN-PT carried out significant anti-tumor activities against OS both in vitro and in vivo.
Conclusions: Peptide-based semiconducting polymer nanoparticles permit efficient NIR-II fluorescence/NIR-I PA dual-modal imaging and targeted PTT/PDT for OS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780402 | PMC |
| http://dx.doi.org/10.1186/s12951-022-01249-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biodegradable semiconducting polymer nanoparticles for phototheranostics.
J Mater Chem B
January 2025
State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
Semiconducting polymer nanoparticles (SPNs) have been widely applied for phototheranostics. However, the disadvantage of long-term metabolism greatly suppresses the clinical application of SPNs. To improve the metabolic rate and minimize the long-term toxicity of SPNs, biodegradable semiconducting polymers (BSPs), whose backbones may be degraded under certain conditions, have been designed.
View Article and Find Full Text PDFSuper-resolution optical fluctuation imaging (SOFI) rapidly generates super-resolution images by analyzing fluorescence intensity fluctuations. However, fluorophores for high-order SOFI applications are very rare. Here, we report ultrasmall semiconducting polymer dots (Pdots) to achieve high-order SOFI at single-particle and cellular levels.
View Article and Find Full Text PDFControllable Self-Assembly Morphologies of PPV-Based Block Copolymers.
Chemistry
January 2025
Southern University of Science and Technology, Chemistry, 1088 Xueyuan Blvd., Xili, Nanshan District, 518055, Shenzhen, CHINA.
Poly(p-phenylenevinylene) (PPV) is a classic semiconducting π-conjugated polymers with outstanding optical and electronic properties, which shows important applications in the fields of optoelectronic, such as organic light-emitting diodes (OLEDs), organic solar cells (OSCs), and organic field-effect transistors (OFETs). In the working process of the device, the microstate of PPV decides its property. Therefore, it is significant to achieve ordered morphologies based on PPV at micro scale.
View Article and Find Full Text PDFVerdazyl radical polymers for advanced organic spintronics.
Nat Commun
January 2025
Charles D. Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, USA.
Spin currents have long been suggested as a potential solution to addressing circuit miniaturization challenges in the semiconductor industry. While many semiconducting materials have been extensively explored for spintronic applications, issues regarding device performance, materials stability, and efficient spin current generation at room temperature persist. Nonconjugated paramagnetic radical polymers offer a unique solution to these challenges.
View Article and Find Full Text PDFQuantitative Analysis of Hepatitis D Virus Using gRNA-Sensitive Semiconducting Polymer Dots.
Anal Chem
January 2025
State Key Laboratory of Integrated Optoelectronics, College of Electronics Science and Engineering, Jilin University, No. 2699 Qianjin Street, Changchun, Jilin 130012, P. R. China.
Hepatitis D virus (HDV) significantly influences the progression of liver diseases. Through clinical observations and database analyses, it has been established that patients coinfected with HDV and hepatitis B virus (HBV) experience accelerated progression toward cirrhosis, hepatocellular carcinoma (HCC), and liver failure compared to those infected solely with HBV. A higher viral load correlates with increased replicative activity, enhanced infectivity, and more severe disease manifestations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!