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Enantioselective reaction of -cyano imines: decarboxylative Mannich-type reaction with malonic acid half thioesters. | LitMetric
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Enantioselective reaction of -cyano imines: decarboxylative Mannich-type reaction with malonic acid half thioesters.

Yusuke Oyamada Kazuto Inaba Takahiro Sasamori Shuichi Nakamura

Chem Commun (Camb)

Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.

Published: February 2022

The enantioselective reaction of imines bearing a cyano group as an activating group with malonic acid half thioesters gave chiral cyanamide derivatives with high enantioselectivity. The density functional theory (DFT) calculation clarified the stereochemical outcome and importance of the -cyano group for imines.

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 Source
http://dx.doi.org/10.1039/d1cc07191bDOI Listing

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