The innate immune system plays a crucial role in cardiovascular disease initiation, progression and complications. TREM-1, a receptor mainly expressed by myeloid cells, orchestrates inflammatory responses and amplifies cytokine and chemokine production as well as oxidative burst. Recent experimental studies have demonstrated that TREM-1 blockade is protective, limiting atherosclerosis and abdominal aortic aneurysm development, as well as adverse tissue remodeling after cardiac or cerebral ischemic injuries. Plasma soluble TREM-1 level is a promising biomarker in patients with cardiovascular diseases for risk stratification, paving the way for personalized immune-modulatory approaches.
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Article Synopsis
- TREM-1 is a protein important for the immune system, and scientists are studying how it affects a disease called obliterative bronchiolitis (OB).
- In a mouse study, they found that blocking TREM-1 helps reduce the problems caused by OB, while boosting it makes things worse.
- The research suggests that targeting TREM-1 could be a useful way to treat OB by changing how immune cells work.
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