AI Article Synopsis
- Anyplex II HPV-28 can individually detect 28 HPV genotypes, and a study compared its effectiveness against linear array HPV genotyping (LA-HPV) in 410 anogenital samples from individuals, primarily women.
- The detection rates showed that HPV-28 identified HPV in 95.9% of samples, while LA-HPV detected it in 93.2%, leading to a high agreement rate of 96.3% between the two methods.
- Both methods had excellent concordance for most HPV types, especially for high-risk genotypes, but HPV-28 was more often positive for specific types like HPV42 and HPV68.
Article Abstract
Anyplex II HPV-28 (HPV-28) can detect individually 28 HPV genotypes. We assessed the agreement between linear array HPV genotyping (LA-HPV) and HPV-28 for detection of 27 HPV genotypes in 410 stored anogenital samples (75 anal samples, 335 physician-collected cervical samples) collected over 5 years from 410 individuals (13 men, 397 women), including 202 HIV-seropositive individuals. HPV DNA was detected in 393 (95.9%, 95% confidence interval [CI]: 93.4-97.4) and 382 (93.2%, 95% CI: 90.3-95.3) samples with HPV-28 and LA-HPV (p = 0.13), respectively, for a good agreement of 96.3% (κ = 0.65). Of the 10503 HPV typing results, 10195 (780 positive, 9577 negative) were concordant, for an agreement of 97.1% (95% CI: 96.7-97.4) and an excellent of κ = 0.82 (95% CI: 0.80-0.84). The mean type-specific concordance for 27 genotypes was 97.0%, 95% CI: 95.8-98.5 (κ = 0.86 ± 0.07, 95% CI: 0.83-0.88). Excellent agreement was obtained individually for all high-risk genotypes (κ = 0.81-0.97) and for most other genotypes except for types 42, 44, 54, 68, and 69. The mean number of types per sample in discordant samples detected with LA-HPV (3.0, 95% CI: 2.7-3.4) was greater than in concordant samples (1.4, 95% CI: 1.3-1.5; p< 0.001). In conclusion, HPV-28 compared favorably with LA-HPV, but was more frequently positive for HPV42 and HPV68.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126003 | PMC |
| http://dx.doi.org/10.1002/jmv.27605 | DOI Listing |
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