Childhood obesity is an increasing condition associated with continuous obesity into adulthood and development of comorbidities. Adult studies show an association between serum uric acid (SUA) levels and body mass index (BMI). The aim of this retro perspective exploratory study was to investigate SUA in obese children and adolescents and the effects of a subsequent weight reduction. One hundred and seventy-one children (age 4-18), with obesity (i.e. BMI-SDS of +2 or higher) were included in a multifactorial lifestyle intervention. The children participating were annually measured for anthropometrics, blood samples and DEXA-scans for up to 3 years. Eighty-nine children were included for follow-up analysis. After a follow-up of 20.7 ± 9.4 months a reduction in BMI-SDS of -0.34 ± 0.53 ( < 0.01) was observed. SUA was found to be positively associated with changes in BMI-SDS. SUA levels decreased in the 65 children who lost weight during the trial, conversely, SUA increased in the 23 children who gained weight during the trial ( < 0.01 between groups). SUA was found to correlate with measures of obesity and for the first time, this intervention demonstrates a positive relationship between SUA and weight reduction in children with obesity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8764402 | PMC |
| http://dx.doi.org/10.3389/fped.2021.814166 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Machine learning applications in healthcare clinical practice and research.
World J Clin Cases
January 2025
Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, Athens 11527, Greece.
Machine learning (ML) is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis, thus creating machines that can complete tasks otherwise requiring human intelligence. Among its various applications, it has proven groundbreaking in healthcare as well, both in clinical practice and research. In this editorial, we succinctly introduce ML applications and present a study, featured in the latest issue of the .
View Article and Find Full Text PDFU-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study.
Front Oncol
December 2024
The First Clinical Medical School, Lanzhou University, Lanzhou, China.
Objective: We conducted this study to investigate the relationship between serum uric acid (SUA) levels and the risk of upper gastrointestinal cancer.
Methods: We conducted a prospective cohort study with 475659 cancer-free participants from the UK Biobank. All subjects were grouped into quartiles, and we used a Cox proportional hazards model to analyze the association between SUA levels and the risk of upper gastrointestinal cancer and explore the potential sex-specific relationship.
Pertinence between Preoperative Renal Function and Composition of Renal Calculi in Elderly Patients: A Retrospective Analysis.
Arch Esp Urol
December 2024
Department of Laboratory Medicine, Wenzhou People's Hospital; The Third Affiliated Hospital of Shanghai University; The Wenzhou Third Clinical College of Wenzhou Medical University, 325000 Wenzhou, Zhejiang, China.
Background: Kidney stone disease poses a significant challenge in the geriatric population. Preoperative renal function has been speculated to influence the composition of renal calculi, and consequently, the management approach. We studied the correlation between preoperative renal function and the composition of renal calculi in elderly patients, which could have implications for optimizing therapeutic strategies.
View Article and Find Full Text PDFThe effects and predictive values of novel anthropometric parameters on uric acid levels and hyperuricemia in adults.
Sci Rep
January 2025
Department of Cardiovascular Medicine, Jiangsu Provincial People's Hospital Group Taihu Sanatorium of Jiangsu Province, Wuxi, 214086, China.
Novel anthropometric indices are more closely related to metabolic abnormalities than traditional anthropometric indices. Fewer studies have been conducted based on the relationship between novel anthropometric indicators and hyperuricemia. This study was to analyze the serum uric acid (SUA) levels of adults and the relationship between hyperuricemia and these new indicators in Su-Wuxi-Chang area of China, in order to provide a theoretical basis for the management of SUA levels in patients with hyperuricemia.
View Article and Find Full Text PDFSubstrate preference triggers metabolic patterns of indigenous microbiome during initial composting stages.
Bioresour Technol
January 2025
Jiangsu Provincial Key Lab of Solid Organic Waste Utilization, Jiangsu Collaborative Innovation Center of Solid Organic Wastes, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China. Electronic address:
Composting organic waste is a sustainable recycling method in agricultural systems, yet the microbial preferences for different substrates and their influence on composting efficiency remain underexplored. Here, 210 datasets of published 16S ribosomal DNA amplicon sequences from straw and manure composts worldwide were analyzed, and a database of 278 bacterial isolates was compiled. Substrate-driven microbiome variations were most prominent during the initial composting stages.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!