A recent antimalarial screen by Alder and colleagues has uncovered a natural product, PDE-I, with DNA-binding and schizonticidal activity against Plasmodium falciparum. Parasite specificity is likely conferred by the extremely high A+T content of the P. falciparum genome. We discuss here this character as a potential target for future drugs.
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| http://dx.doi.org/10.1016/j.tips.2022.01.003 | DOI Listing |
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