UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779573 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics14010072 | DOI Listing |
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