Green Synthesis of Indeno[1,2-b]quinoxalines Using β-Cyclodextrin as Catalyst.

Molecules

Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.

Published: January 2022

An efficient, mild, and green method was developed for the synthesis of indeno[1,2-b]quinoxaline derivatives via o-phenylenediamine (OPD) and 2-indanone derivatives utilizing -cyclodextrin (-CD) as the supramolecular catalyst. The reaction can be carried out in water and in a solid state at room temperature. -CD can also catalyze the reaction of indan-1,2-dione with OPD with a high degree of efficiency. Compared to the reported methods, this procedure is milder, simpler, and less toxic, making it an eco-friendly alternative. In addition, the -CD can be recovered and reused without the loss of activity.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779894PMC
http://dx.doi.org/10.3390/molecules27020580DOI Listing

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