Background: Macroaggregated human serum albumin (MAA) properties are widely used in nuclear medicine, labelled with Tc. The aim of this study is to improve the knowledge about the morphology, size, dimension and physical-chemical characteristics of MAA and their bond with Tc and Ga.
Methods: Commercial kits of MAA (Pulmocis) were used. Characterisation through experiments based on SEM, DLS and Stokes' Law were carried out. In vitro experiments for Langmuir isotherms and pH studies on radiolabelling were performed and the stability of the radiometal complex was verified through competition reactions.
Results: The study settles the MAA dimension within the range 43-51 μm. The Langmuir isotherm reveals for [Tc]MAA: Bmax (46.32), h (2.36); for [Ga]MAA: Bmax (44.54), h (0.893). Dual labelling reveals that MAA does not discriminate different radioisotopes. Experiments on pH placed the optimal pH for labelling with Tc at 6.
Conclusion: Radiolabelling of MAA is possible with high efficiency. The nondiscriminatory MAA bonds make this drug suitable for radiolabelling with different radioisotopes or for dual labelling. This finding illustrates the need to continue investigating MAA chemical and physical characteristics to allow for secure labelling with different isotopes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777888 | PMC |
| http://dx.doi.org/10.3390/molecules27020404 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Non-phosgene route: catalytic carbonylation of amines to form unsymmetrical ureas.
Natl Sci Rev
January 2025
State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, College of Chemistry and Chemical Engineering, Xiamen University, China.
Functionalized Periosteum-Derived Microsphere-Hydrogel with Sequential Release of E7 Short Peptide/miR217 for Large Bone Defect Repairing.
Biomater Res
January 2025
Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310000, China.
Large bone defects are still a persistent challenge in orthopedics. The availability limitations and associated complications of autologous and allogeneic bone have prompted an increasing reliance on tissue engineering and regenerative medicine. In this study, we developed an injectable scaffold combining an acellular extracellular periosteal matrix hydrogel with poly(d,l-lactate--glycol-acetate) microspheres loaded with the E7 peptide and miR217 (miR217/E7@MP-GEL).
View Article and Find Full Text PDFUnderstanding ammonia's role in mitigating concentration polarization in anion-exchange membrane electrodialysis.
Turk J Chem
December 2024
Laboratory of Physical Chemistry of Materials (LPCM), Faculty of Sciences, University of Amar Telidji, Laghouat, Algeria.
In processes such as electrodialysis, the applied electrical potential is constrained by concentration polarization at the membrane/solution interface. This polarization, which intensifies at higher current densities, impedes ion transport efficiency and may lead to problems such as salt precipitation, membrane degradation, and increased energy consumption. Therefore, understanding concentration polarization is essential for enhancing membrane performance, improving efficiency, and reducing operational costs.
View Article and Find Full Text PDFAnalysis and optimization of the adsorption of lead ions on a new material based on silica synthesized from blast furnace slag.
Turk J Chem
November 2024
Research Center in Industrial Technologies CRTI, Algiers, Algeria.
A novel silica-based material (SBM), synthesized from chemically-, thermally-, and mechanically-treated blast furnace slag (TBFS), was examined for its batch-mode lead adsorption capacity based on various parameters. Physicochemical examinations revealed that the formulation of the new SBM consisted mainly of silica, which represented 81.79% of its total composition.
View Article and Find Full Text PDFPost-Degradation Recovery of CsPbI Quantum Dot Solar Cells.
Small
January 2025
Chair for Emerging Electronic Technologies, TUD Dresden University of Technology, Nöthnitzer Straße 61, 01187, Dresden, Germany.
The stability of perovskite quantum dot solar cells is one of the key challenges of this technology. This study reveals the unique degradation behavior of cesium lead triiodide (CsPbI) quantum dot solar cells. For the first time, it is shown that the oxygen-induced degradation and performance loss of CsPbI quantum dot photovoltaic devices can be reversed by exposing the degraded samples to humidity, allowing the performance to recover and even surpass the initial performance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!