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A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology. | LitMetric

A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology.

Micromachines (Basel)

Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.

Published: December 2021

AI Article Synopsis

Article Abstract

In recent years, there has been an increased interest in exploring the potential of micro-and mesoscale milling technologies for developing cost-effective microfluidic systems with high design flexibility and a rapid microfabrication process that does not require a cleanroom. Nevertheless, the number of current studies aiming to fully understand and establish the benefits of this technique in developing high-quality microsystems with simple integrability is still limited. In the first part of this study, we define a systematic and adaptable strategy for developing high-quality poly(methyl methacrylate) (PMMA)-based micromilled structures. A case study of the average surface roughness () minimization of a cuboid column is presented to better illustrate some of the developed strategies. In this example, the of a cuboid column was reduced from 1.68 μm to 0.223 μm by implementing milling optimization and postprocessing steps. In the second part of this paper, new strategies for developing a 3D microsystem were introduced by using a specifically designed negative PMMA master mold for polydimethylsiloxane (PDMS) double-casting prototyping. The reported results in this study demonstrate the robustness of the proposed approach for developing microfluidic structures with high surface quality and structural integrability in a reasonable amount of time.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779272PMC
http://dx.doi.org/10.3390/mi13010006DOI Listing

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