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Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction. | LitMetric

AI Article Synopsis

  • The study investigates the significance of a newly proposed target heart rate (THR) formula for patients with heart failure with reduced ejection fraction (HFrEF), focusing on the prevention of hospital readmissions and all-cause death.
  • Researchers analyzed data from 647 patients with HFrEF who were hospitalized for acute decompensated heart failure, comparing outcomes based on THR versus a standard heart rate of 70 bpm.
  • Findings indicate that using THR to assess heart rates at discharge can better predict long-term health outcomes, suggesting it may be beneficial for personalized heart rate management strategies in HFrEF patients.

Article Abstract

The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic significance in the multicenter WET-HF registry. This study used data from 647 patients with HFrEF hospitalized for acute decompensated HF (ADHF). The patients were divided into the 2 groups by THR. The primary endpoint was defined as the composite of all-cause death and ADHF readmission. The THR successfully discriminated the incidence of the primary endpoint, whereas no significant difference was observed in the primary endpoint when dividing the patients by uniform cutoff 70 bpm. HR at discharge ≤ THR was inversely associated with the primary endpoint. Restricted cubic spline analysis demonstrated the difference between HR at discharge, and THR (ΔHR) from -10 to ±0 was associated with a lower risk of primary endpoint and ΔHR from ±0 to +15 was associated with a higher risk. THR discriminated long-term outcomes in patients with HFrEF more efficiently than the uniform cutoff, suggesting that it may aid in tailored HR reduction strategies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777886PMC
http://dx.doi.org/10.3390/jpm12010050DOI Listing

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