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Could Overgrowth Be Involved in the Pathophysiology of Autism? | LitMetric

Could Overgrowth Be Involved in the Pathophysiology of Autism?

J Clin Med

Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, Poland.

Published: January 2022

AI Article Synopsis

Article Abstract

The purpose of this review is to summarize the current acquiredknowledge of overgrowth in the intestine as a possible etiology of autism spectrum disorder (ASD). The influence of sp. on the immune system, brain, and behavior of children with ASD isdescribed. The benefits of interventions such as a carbohydrates-exclusion diet, probiotic supplementation, antifungal agents, fecal microbiota transplantation (FMT), and microbiota transfer therapy (MTT) will be also discussed. Our literature query showed that the results of most studies do not fully support the hypothesis that overgrowth is correlated with gastrointestinal (GI) problems and contributes to autism behavioral symptoms occurrence. On the one hand, it was reported that the modulation of microbiota composition in the gut may decrease overgrowth, help reduce GI problems and autism symptoms. On the other hand, studies on humans suggesting the beneficial effects of a sugar-free diet, probiotic supplementation, FMT and MTT treatment in ASD are limited and inconclusive. Due to the increasing prevalence of ASD, studies on the etiology of this disorder are extremely needed and valuable. However, to elucidate the possible involvement of in the pathophysiology of ASD, more reliable and well-designed research is certainly required.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778531PMC
http://dx.doi.org/10.3390/jcm11020442DOI Listing

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