Patients with stroke suffer from impaired locomotion, exhibiting unstable walking with increased gait variability. Effects of rhythmic sensory stimulation on unstable gait of patients with chronic stroke are unclear. This study aims to determine the effects of rhythmic sensory stimulation on the gait of patients with chronic stroke. Twenty older adults with stroke and twenty age- and gender-matched healthy controls walked 60 m under four conditions: normal walking with no stimulation, walking with rhythmic auditory stimulation (RAS) through an earphone in the ear, walking with rhythmic somatosensory stimulation (RSS) through a haptic device on the wrist of each participant, and walking with rhythmic combined stimulation (RCS: RAS + RSS). Gait performance in the stroke group significantly improved during walking with RAS, RSS, and RCS compared to that during normal walking ( < 0.008). Gait variability significantly decreased under the RAS, RSS, and RCS conditions compared to that during normal walking ( < 0.008). Rhythmic sensory stimulation is effective in improving the gait of patients with chronic stroke, regardless of the type of rhythmic stimuli, compared to healthy controls. The effect was greater in patients with reduced mobility, assessed by the Rivermead Mobility Index (RMI).
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http://dx.doi.org/10.3390/jcm11020425 | DOI Listing |
Front Bioeng Biotechnol
January 2025
Department of Orthopaedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical Universit, Guangzhou, China.
Objective: The aim of this study is to assess the kinematic changes in the knee joint during walking in patients with isolated PCL-deficiency (PCLD) to determine the presence of walking-related joint instability (mechanical instability-abnormal displacement form structural damage). Additionally, the study seeks to provide biomechanical insights into the observed differences between subjective and objective assessments.
Methods: 35 healthy volunteers and 27 patients with isolated PCLD (both involved and uninvolved sides) were included in the study.
Quant Imaging Med Surg
January 2025
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Background: There are currently no deep learning models applying resting-state functional magnetic resonance imaging (rs-fMRI) data to distinguish patients with Parkinson's disease (PD) and healthy controls (HCs). Moreover, no study has correlated objective gait parameters with brain network alterations in patients with PD. We propose BrainNetCNN + CL, applying a convolutional neural network (CNN) and joint contrastive learning (CL) method to brain network analysis to classify patients with PD and HCs, and compare their performance with classical classification methods.
View Article and Find Full Text PDFQuant Imaging Med Surg
January 2025
Emergency and Outpatient Department, China-Japan Union Hospital of Jilin University, Changchun, China.
Background: Preliminary scientific evidence suggests that freezing of gait (FoG) in patients with Parkinson disease (PD) is linked to noradrenergic dysfunction in the locus coeruleus (LC). However, definitive findings regarding the correlation between FoG occurrence and the LC are lacking. This study thus aimed to investigate the relationship between the FoG occurrence and LC degeneration in patients with PD by analyzing the signal characteristics of the LC in neuromelanin-sensitive magnetic resonance imaging (NM-MRI).
View Article and Find Full Text PDFEur J Neurol
January 2025
Research Unit, Hospital Universitario Burgos, Burgos, Spain.
Background And Purpose: Adopting telemedicine (TM) enables improved access to specialized care and reduces barriers. The aim was to assess the cost-utility of a coadjutant multidisciplinary TM programme for fall prevention compared to standard in-office visits for individuals with Parkinson's disease (PD).
Methods: This was an 8-month single-blind randomized controlled trial.
J Transl Med
January 2025
Department of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (ON). According to the statistics, up to 50% of MS patients experience vision problems during the disease course, suffering from blurred vision, pain, color vision deficits, and even blindness. Treatments have progressed from corticosteroids to therapies targeted against B/T cells.
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