AI Article Synopsis
- TRIM36 is a member of the TRIM family of proteins, primarily known for its role in the acrosome reaction of sperm and its abundance in testicular tissue.* -
- This protein acts as a microtubule-associated E3 ubiquitin ligase, influencing cell growth speed, stability, and progression through the cell cycle by acting on the plus end of microtubules.* -
- TRIM36 is essential for early developmental processes, affecting dorso-ventral axis formation and is linked to severe neural tube defects in humans when mutated.*
Article Abstract
TRIM36 is a member of the tripartite motif (TRIM) family of RING-containing proteins, also known as Haprin, which was first discovered for its abundance in testis and found to be implicated in the spermatozoa acrosome reaction. TRIM36 is a microtubule-associated E3 ubiquitin ligase that plays a role in cytoskeletal organization, and according to data gathered in different species, coordinates growth speed and stability, acting on the microtubules' plus end, and impacting on cell cycle progression. TRIM36 is also crucial for early developmental processes, in , where it is needed for dorso-ventral axis formation, but also in humans as bi-allelic mutations in the TRIM36 gene cause a form of severe neural tube closure defect, called anencephaly. Here, we review TRIM36-related mechanisms implicated in such composite physiological and pathological processes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773809 | PMC |
| http://dx.doi.org/10.3390/cells11020246 | DOI Listing |
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