AI Article Synopsis
- The text discusses the significance of Klebsiella pneumoniae (KP) as a hospital pathogen, distinguishing between classical (cKp) and hypervirulent (hvKp) strains, as well as the emergence of hybrid strains with multi-drug resistance (MDR)!
- A study of 70 distinct isolates in a Moscow neurosurgery ICU from 2014-2019 identified 20 genetic sequence types, highlighting the prevalence of specific strains and high rates of MDR (84.3%) and carbapenem resistance (45.7%)!
- Whole-genome sequencing of selected strains revealed various important genes related to resistance and virulence, suggesting that understanding these genetic factors is crucial for both epidemiologists and clinicians in
Article Abstract
is an increasingly important hospital pathogen. Classical (cKp) and hypervirulent (hvKp) are two distinct evolutionary genetic lines. The recently ongoing evolution of resulted in the generation of hybrid hvKP-MDR strains. distinct isolates ( = 70) belonged to 20 sequence types with the prevalence of ST395 (27.1%), ST23 (18.6%), ST147 (15.7%), and ST86 (7.1%), and 17 capsular types with the predominance of K2 (31.4%), K57 (18.6%), K64 (10.0%), K1 (5.7%) were isolated from patients of the Moscow neurosurgery ICU in 2014-2019. The rate of multi-drug resistant (MDR) and carbapenem-resistant phenotypes were 84.3% and 45.7%, respectively. Whole-genome sequencing of five selected strains belonging to cKp (ST395 and ST147), hvKp (ST86), and hvKp-MDR (ST23 and ST23) revealed , , , , and beta-lactamase genes; , , , , and efflux genes; and virulence genes. Selective pressure of 100 mg/L ampicillin or 10 mg/L ceftriaxone induced changes of expression levels for named genes in the strains belonging to cKp, hvKp, and hybrid hvKp-MDR. Obtained results seem to be important for epidemiologists and clinicians for enhancing knowledge about hospital pathogens.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773033 | PMC |
| http://dx.doi.org/10.3390/antibiotics11010007 | DOI Listing |
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