AI Article Synopsis
- The human plasma proteome reflects the cardiovascular system's state, aiding in the diagnosis and monitoring of certain cardiovascular diseases but is limited to a small number of conditions like myocardial infarction.
- Recent increases in cardiovascular conditions, such as heart failure, highlight the urgent need for new plasma biomarkers for diagnosis and stratification.
- Advances in proteomic analysis technologies are improving the ability to discover novel plasma biomarkers that could enhance cardiovascular disease management.
Article Abstract
The human plasma proteome mirrors the physiological state of the cardiovascular system, a fact that has been used to analyze plasma biomarkers in routine analysis for the diagnosis and monitoring of cardiovascular diseases for decades. These biomarkers address, however, only a very limited subset of cardiovascular diseases, such as acute myocardial infarct or acute deep vein thrombosis, and clinical plasma biomarkers for the diagnosis and stratification cardiovascular diseases that are growing in incidence, such as heart failure and abdominal aortic aneurysm, do not exist and are urgently needed. The discovery of novel biomarkers in plasma has been hindered by the complexity of the human plasma proteome that again transforms into an extreme analytical complexity when it comes to the discovery of novel plasma biomarkers. This complexity is, however, addressed by recent achievements in technologies for analyzing the human plasma proteome, thereby facilitating the possibility for novel biomarker discoveries. The aims of this article is to provide an overview of the recent achievements in technologies for proteomic analysis of the human plasma proteome and their applications in cardiovascular medicine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773619 | PMC |
| http://dx.doi.org/10.3390/biomedicines10010162 | DOI Listing |
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