The antioxidant defense system is involved in the pathogenesis of neonatal hypoxic-ischemic encephalopathy (HIE). To analyze the relationship between first serum blood glucose levels and outcomes in neonatal HIE, seventy-four patients were divided, based on the first glucose level, into group 1 (>0 mg/dL and <60 mg/dL, =11), group 2 (≥60 mg/dL and <150 mg/dL, = 49), and group 3 (≥150 mg/dL, = 14). Abnormal glucose levels had poor outcomes among three groups in terms of the clinical stage 0.001), brain parenchymal lesion = 0.004), and neurodevelopmental outcomes = 0.029). Hearing impairment was more common in group 3 than in group 1 ( = 0.062) and group 2 ( = 0.010). The MRI findings of group 3 exhibited more thalamus and basal ganglion lesions than those of group 1 = 0.012). The glucose level was significantly correlated with clinical staging ( 0.001), parenchymal brain lesions ( = 0.044), hearing impairment ( = 0.003), and neurodevelopmental outcomes ( = 0.005) by Pearson's test. The first blood glucose level in neonatal HIE is an important biomarker for clinical staging, MRI findings, as well as hearing and neurodevelopment outcomes. Hyperglycemic patients had a higher odds ratio for thalamus, basal ganglia, and brain stem lesions than hypoglycemic patients with white matter and focal ischemic injury. Hyperglycemia can be due to prolonged or intermittent hypoxia and can be associated with poor outcomes.
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http://dx.doi.org/10.3390/antiox11010039 | DOI Listing |
Front Clin Diabetes Healthc
January 2025
Department of Endocrinology and Diabetes, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.
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Design & Methods: Retrospective cross-sectional study investigating the influence of demographic factors, technology use, and socioeconomic status (SES) on glycaemic outcomes.
PeerJ
January 2025
Faculty of Fisheries, Muğla Sıtkı Koçman University, Muğla, Türkiye.
This study aims to determine and compare the reference values of the haematological and biochemical blood parameters of two fish species collected from the Gökova Bay (Muğla, South-Western of Türkiye): the non-native and invasive Randall's threadfin bream, and the native Common pandora, . Both species inhabit the same environment and compete for resources. Blood samples were collected from a total of 100 fish samples (50 and 50 ) which were caught from a depth of 30 to 60 meters between February 2023 and July 2024.
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January 2025
Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Background: Fatty Liver Disease (FLD) progresses from steatosis to steatohepatitis and, if left untreated, can lead to irreversible conditions such as cirrhosis and hepatocarcinoma. The etiology of FLD remains unclear, but factors such as overconsumption, poor diet, obesity, and diabetes contribute to its development. Palmitic acid (PA) plays a significant role in FLD progression by inducing apoptosis, inflammation, oxidative stress, and endoplasmic reticulum (ER) stress in hepatocytes.
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Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
The investigation of microRNAs (miRNAs) for the purpose of identifying biomarkers and new treatments for breast cancer has been gaining traction from scientists in recent years. Of all the miRNAs, miR-155 has been reportedly involved in breast cancer development as it regulates various cellular processes such as glucose uptake, proliferation, metastasis, and migration. Various efforts have been done towards researching miR-155 as a biomarker in breast cancer; however, the results were varied.
View Article and Find Full Text PDFJ Diabetes Res
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Renal Research Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital & The University of Sydney, Sydney, Australia.
Emerging evidence suggests cell exfoliation could be operating under the control of cell metabolism. It is unclear if there are associations between the concentration of exfoliated kidney proximal tubule cells (PTCs) in urine with glycemic control and complications. Our study is aimed at exploring this.
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