Store-operated Ca entry (SOCE) is a major mechanism controlling Ca signaling and Ca-dependent functions and has been implicated in immunity, cancer, and organ development. SOCE-dependent cytosolic Ca signals are affected by mitochondrial Ca transport through several competing mechanisms. However, how these mechanisms interact in shaping Ca dynamics and regulating Ca-dependent functions remains unclear. In a recent issue, Yoast et al. shed light on these questions by defining multiple roles of the mitochondrial Ca uniporter in regulating SOCE, Ca dynamics, transcription, and lymphocyte activation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819027 | PMC |
| http://dx.doi.org/10.1016/j.jbc.2022.101604 | DOI Listing |
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