AI Article Synopsis
- A study evaluated the levels of soluble TIM-3 (sTIM-3) in patients with oral squamous cell carcinoma (OSCC) to assess its potential as a clinical diagnostic marker.
- The researchers measured sTIM-3 and squamous cell carcinoma antigen (SCCAg) levels in 199 OSCC patients and 107 healthy individuals using an enzyme-linked immunosorbent assay.
- Results indicated that both sTIM-3 and SCCAg levels were higher in OSCC patients, and using them together provided better diagnostic accuracy than using each marker alone; sTIM-3 also correlated positively with various clinical factors.
Article Abstract
To evaluate the soluble TIM-3 (sTIM-3) expression level in oral squamous cell carcinoma (OSCC) and determine its clinical diagnostic potential. The sTIM-3 and squamous cell carcinoma antigen (SCCAg) levels of 199 OSCC patients and 107 healthy individuals were assessed using an enzyme-linked immunosorbent assay and their individual and combined efficiency rates were compared. The results showed higher sTIM-3 and SCCAg levels in the OSCC patients and better diagnostic potential for a combination of these markers than for their individual assessments, as well as positive correlation of sTIM-3 levels with clinicopathological factors. sTIM-3 is a potential novel and readily accessible OSCC biomarker, which in combination with SCCAg expression level might better diagnose OSCC patients.
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| http://dx.doi.org/10.2217/fon-2021-1379 | DOI Listing |
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