CO fixation into electron-deficient aromatic C-H bonds proceeds with the combined Brønsted bases LiO--Bu and LiO--Am/CsF/18-crown-6 (-Am = CEtMe) under a CO atmosphere to afford a variety of polyfunctionalized aromatic carboxylic acids.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c03866 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cobalt-catalyzed conformationally restricted alkylarylation enables divergent access to Csp-rich N-heterocycles.
Chem Sci
September 2024
Key Laboratory of Organic Synthesis of Jiangsu Province, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Key Laboratory of Pathogen Bioscience and Anti-infective Medicine, College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou 215123 China
Article Synopsis
- Csp-rich N-heterocycles are gaining attention in drug discovery due to their unique structure and spatial orientation, surpassing traditional aromatic compounds.
- A new cobalt-catalyzed alkylarylation method allows for the efficient creation of diverse Csp-rich N-hetero(spiro)cycles using simple conditions, achieving over 70 different structures.
- The methodology shows great promise for medicinal chemistry, as it offers broad applicability with good compatibility for functional groups and potential for developing pharmaceutically active molecules.
A polyfunctionalized carbon framework composite for efficient decontamination of Cr(VI) and polycyclic aromatic nitrides from acidic wastewater.
Environ Sci Pollut Res Int
June 2024
College of Natural Resources and Environment, Northwest A&F University, Yangling, 712100, Shaanxi Province, China.
Developing multifunctional engineered adsorbents is an effective strategy for decontaminating the environment from various pollutants. In this study, a polyfunctionalized carbon-framework composite, MSC-CFM, was synthesized. The composite comprises an aromatic carbon framework enriched with various functional groups, including magnetic nanoparticles, hydroxyl, and amino groups.
View Article and Find Full Text PDFSite-Selective Ortho/Ipso C-H Difunctionalizations of Arenes using Thianthrene as a Leaving Group.
Angew Chem Int Ed Engl
July 2024
INSA Rouen Normandie, Univ Rouen Normandie, CNRS, Normandie Univ, COBRA UMR 6014, F-76000, Rouen, France.
Site-selective ortho/ipso C-H difunctionalizations of aromatic compounds were designed to afford polyfunctionalized arenes including challenging 1,2,3,4-tetrasubstituted ones (62 examples, up to 97 % yields). To ensure the excellent regioselectivity of the process while keeping high efficiency, an original strategy based on a "C-H thianthenation/Catellani-type reaction" sequence was developed starting from simple arenes. Non-prefunctionalized arenes were first regioselectively converted into the corresponding thianthrenium salts.
View Article and Find Full Text PDFDehydrogenative synthesis of -functionalized 2-aminophenols from cyclohexanones and amines: Molecular complexities via one-shot assembly.
Sci Adv
May 2024
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou 350002, China.
Polyfunctionalized arenes are privileged structural motifs in both academic and industrial chemistry. Conventional methods for accessing this class of chemicals usually involve stepwise modification of phenyl rings, often necessitating expensive noble metal catalysts and suffering from low reactivity and selectivity when introducing multiple functionalities. We herein report dehydrogenative synthesis of -functionalized 2-aminophenols from cyclohexanones and amines.
View Article and Find Full Text PDFRecent synthetic strategies for the construction of functionalized carbazoles and their heterocyclic motifs enabled by Lewis acids.
RSC Adv
October 2023
Department of Chemistry, National Institute of Technology Puducherry Karaikal-609609 Union Territory Puducherry India https://vasudeva49.wixsite.com/catalysislab
This article demonstrates recent innovative cascade annulation methods for preparing functionalized carbazoles and their related polyaromatic heterocyclic compounds enabled by Lewis acid catalysts. Highly substituted carbazole scaffolds were synthesized Lewis acid mediated Friedel-Crafts arylation, electrocyclization, intramolecular cyclization, cycloaddition, C-N bond-formations, aromatization and cascade domino reactions, metal-catalyzed, iodine catalyzed reactions and multi-component reactions. This review article mainly focuses on Lewis acid-mediated recent synthetic methods to access a variety of electron-rich and electron-poor functional groups substituted carbazole frameworks in one-pot reactions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!