Objective: To explore the effects of interventional therapy with bronchoscopy in children with acquired subglottic stenosis (SGS).
Methods: The clinical data of ten pediatric inpatients with acquired SGS who were admitted to Children's Hospital of Chongqing Medical University, as well as their follow-up information obtained 1 week, 1 month, 3 months and 6 months after the procedure was done.were retrospectively analyzed to examine the effect of interventional bronchoscopic therapies, including balloon dilatation, holmium laser, and cryotherapy, in pediatric patients with acquired SGS.
Results: Among the 10 patients with acquired SGS, there were 5 boys and 5 girls aged between 1 month and 6 years and 5 months, with a median age of 11 months and 1 day. Among the 5 patients with acute acquired SGS, two were treated with balloon dilatation only, with one cured and one showing clinical improvement, while three received comprehensive interventional therapy combining balloon dilatation, holmium laser, and cryotherapy, with two cured and one showing improvement. Among the 5 patients with chronic acquired SGS, four cases were cured with comprehensive interventional therapy, while one case suffered from aggravated upper airway obstruction 4 hours after balloon dilatation. The patient was subsequently put on invasive mechanical ventilation for 4 days, but was unable to be extubated. The parents signed do-not-resuscitate order and the patient died afterwards. Bronchoscopy performed 1 week, 1 month and 3 months after the procedure was done showed that the SGS was improved to varying degrees.
Conclusion: Bronchoscopy intervention is an effective therapy for acquired SGS in children.
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http://dx.doi.org/10.12182/20220160109 | DOI Listing |
Curr Oncol
November 2024
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Prostate Imaging Reporting and Data System version 2.1 (PI-RADS) category 3 lesions are a challenge in the clinical workflow. A better detection of the infrequently occurring clinically significant prostate cancer (csPCa) in PI-RADS 3 lesions is an important objective.
View Article and Find Full Text PDFOpen Forum Infect Dis
September 2024
University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Laryngoscope
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, 75390, U.S.A.
Objectives: To determine the incidence of subglottic stenosis (SGS) in children after tracheostomy and identify risk factors for development.
Study Design: Retrospective cohort.
Methods: All patients (<18 years) undergoing tracheostomy at a tertiary children's hospital between 2015 and 2020 were included.
iScience
August 2024
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville TN 37996, USA.
Exosomes/extracellular vesicles (EVs) are essential for the successful transmission of flaviviruses from vector to vertebrate host. Arthropod-EVs are envisioned as important target for blocking the transmission of vector-borne viral diseases. In this study, we show that the selective inhibition of EVs secretion by sphingomyelinase inhibitor, GW4869 significantly reduces vector efficiency and competence in acquiring and transmitting tick-borne flaviviruses.
View Article and Find Full Text PDFJ Plant Physiol
March 2024
Department of Physiology and Cell Biology, Applied Biochemistry, Leibniz Institute of Plant Genetics and Crop Plant Research, 06466 Seeland/OT Gatersleben, Germany. Electronic address:
Androgenetically-derived haploids can be obtained by inducing embryogenesis in microspores. Thus, full homozygosity is achieved in a single generation, oppositely to conventional plant breeding programs. Here, the metabolite profile of embryogenic microspores of Triticum aestivum was acquired and integrated with transcriptomic existing data from the same samples in an effort to identify the key metabolic processes occurring during the early stages of microspore embryogenesis.
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