Photoredox catalyzed cascade CF addition/chemodivergent annulations of -alkenyl aryl ureas.

Herein, we report a substrate-controlled cascade cyclization of -alkenyl aryl ureas, an ambident nucleophile for constructing functionalized heterocycles such as 2-amino-1,3-benzoxazines and dihydroquinazolinones in a chemodivergent fashion using photoredox catalysis under mild conditions. The versatility of the method has been successfully demonstrated by applying this strategy to a wide range of substrates and for the synthesis of functionalized etifoxine drug derivatives.