The emergence of mental health problems during a pandemic is a major concern of healthcare systems. This cross-sectional, analytical study was performed on 1072 patients with COVID-19 disease without pre-existing mental disorders in Kurdistan Province in 2020 to obtain the frequency of depression, anxiety, and stress using a valid, standard electronic depression, anxiety, and stress scale-21 questionnaire. Data analyses were conducted in SPSS Version 23 using logistic regression modeling. The mean age of the participants was 31.91 ± 10.28 years and 543 subjects (50.7%) were female. The prevalence of stress, anxiety, and depression was 51.7% (95% confidence interval [CI]: 48.7-54.7), 64.3% (95% CI: 61.3-67.1), 61.4% (95% CI: 58.4-64.2), respectively. The prevalence of depression, anxiety, and stress was higher in the employees and retirees compared to the unemployed and homemakers (P < 0.05). Furthermore, the frequency of stress (odds ratio [OR]: 1.36, P = 0.01) and depression (OR: 1.3, P = 0.04) in patients who undertook severe protection measures was significantly higher than those who used lower. The patients with COVID-19 experienced high levels of depression, anxiety, and stress. Therefore, it is essential to provide psychological and psychiatric services to these patients electronically or face to face at health centers.
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