Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1158/1078-0432.CCR-21-4242 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Erratum: Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer.
Int J Clin Exp Pathol
November 2024
Department of Child Health Care, The Affiliated Hospital of Qingdao University Qingdao 266003, Shandong, P. R. China.
[This corrects the article on p. 11076 in vol. 8, PMID: 26617826.
View Article and Find Full Text PDFCorrection: STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A.
J Exp Clin Cancer Res
October 2024
Department of Biliary-Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei, 430074, China.
An epigenetic human cytomegalovirus infection score predicts viremia risk in seropositive lung transplant recipients.
Epigenetics
December 2024
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Article Synopsis
- Cytomegalovirus (CMV) infection in solid organ transplant recipients significantly raises the chances of complications such as viremia (viral presence in blood), graft failure, and even death.
- Research shows that solid organ transplant recipients who received organs from CMV-positive donors are at a higher risk of viremia compared to those who received organs from CMV-negative donors.
- A study profiling DNA methylation in transplant candidates found that CMV-positive recipients exhibit an altered immune epigenome, leading to potential biomarkers, like the CMV episcore, which could help predict viremia risk in these patients post-transplant.
Methylation, Gene Expression, and Risk Genotypes at the TERT-CLPTM1L Locus in Cervical Cancer.
Mol Carcinog
January 2025
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Article Synopsis
- The study examines the role of TERT, a subunit of telomerase, in high-grade cervical cancer, highlighting its activation linked to hypomethylation as a potential biomarker for disease progression.
- Researchers analyzed 529 CpG sites in the TERT promoter region and related areas, discovering specific sites whose methylation patterns are significantly associated with genetic variants that increase cervical cancer risk.
- Findings suggest that certain genetic variants are linked to lower levels of TERT and CLPTM1L mRNA, indicating a protective effect against cervical cancer, while HPV infection appears to increase levels of these genes.
Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.
Biol Sex Differ
August 2024
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8635 West 3rd Street, Suite 160, Los Angeles, CA, 90048, USA.
Background: Fetal sex and placental development impact pregnancy outcomes and fetal-maternal health, but the critical timepoint of placenta establishment in first trimester is understudied in human pregnancies.
Methods: Pregnant subjects were recruited in late first trimester (weeks 10-14) at time of chorionic villus sampling, a prenatal diagnostic test. Leftover placenta tissue was collected and stored until birth outcomes were known, then DNA and RNA were isolated from singleton, normal karyotype pregnancies resulting in live births.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!