AI Article Synopsis
- This study aimed to test the effects of protocatechuic acid (PCA) on tendon healing and fatty degeneration in a rotator cuff injury model using male rats.
- The experiment involved two groups—one receiving PCA and the other saline—both undergoing tendon repair after a 4-week period.
- Results showed that PCA might enhance tendon healing and reduce fatty degeneration, although most observed differences didn’t reach statistical significance.
Article Abstract
Background: The purpose of this study was to verify the effect of protocatechuic acid (PCA) on tendon healing and fatty degeneration in a chronic rotator cuff model.
Methods: Twenty-eight Sprague-Dawley male rats were randomly allocated into two groups: Saline+repair (SR) and PCA+repair (PR). The right shoulder was used for experimental interventions, and the left served as a control. PCA (30 mg/kg/day) was administered intraperitoneally at the site of infraspinatus tendon detachment in rats in the PR group, and the same volume of saline was administered to the same site in the SR group. The torn tendon was repaired 4 weeks after infraspinatus detachment. Four weeks after repair, hematoxylin and eosin (H&E), S100, and CD68 stains were performed to evaluate the degree of fatty degeneration and H&E and Masson trichrome stains were performed to assess tendon healing. Superoxide dismutase (SOD) was measured to test the efficacy of PCA as an antioxidant.
Results: Results from histological evaluation indicated that SOD and CD68 levels at the musculotendinous region and collagen fiber parallel to the orientation at the tendon-to-bone junction were not significantly different between the SR and PR groups. The mean load-to-failure of the PR group (20.32±9.37 N) was higher than that of the SR group (16.44±6.90 N), although this difference was not statistically significant (p=0.395). The SOD activity in the operative side infraspinatus muscle of the PR group was higher than that of the SR group, but the difference was not statistically significant (p=0.053).
Conclusions: The use of PCA could improve tendon healing and decrease fatty degeneration after rotator cuff repair.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907501 | PMC |
| http://dx.doi.org/10.5397/cise.2021.00395 | DOI Listing |
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